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Diaveridine is a coccidiostat used in veterinary medicine that exhibits anti-parasitic activity. Diaveridine inhibits dihydrofolate reductase, preventing folic acid synthesis in species of Pneumocystis. Diaveridine is also genotoxic, inducing structural chromosomal aberrations and inducing DNA damage in vitro.
| Cas No. | 5355-16-8 |
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| Purity | ≥98% |
| Formula | C13H16N4O2 |
| Formula Wt. | 260.29 |
| Chemical Name | 5-[(3,4-Dimethoxyphenyl)methyl]-2,4-pyrimidine- diamine |
| IUPAC Name | 5-[(3,4-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine |
| Synonym | Diaveridin |
| Melting Point | 233°C |
| Solubility | Soluble in HCl or chloroform (1:600). |
| Appearance | White or Almost-White Crystalline Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Ono T, Sekiya T, Takahashi Y, et al. The genotoxicity of diaveridine and trimethoprim. Environ Toxicol Pharmacol. 1997 Sep;3(4):297-306. PMID: 21781790.
Cirioni O, Giacometti A, Scalise G. In-vitro activity of atovaquone, sulphamethoxazole and dapsone alone and combined with inhibitors of dihydrofolate reductase and macrolides against Pneumocystis carinii. J Antimicrob Chemother. 1997 Jan;39(1):45-51. PMID: 9044027.
Walzer PD, Kim CK, Foy JM, et al. Inhibitors of folic acid synthesis in the treatment of experimental Pneumocystis carinii pneumonia. Antimicrob Agents Chemother. 1988 Jan;32(1):96-103. PMID: 3258144.