• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Dimethoxycurcumin

Dimethoxycurcumin

Product ID D3449
Cas No. 160096-59-3
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $200.10 In stock
10 mg $306.20 In stock
25 mg $612.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Like its parent compound, curcumin, this curcuminoid exhibits anticancer, antioxidative, anti-inflammatory, and antibacterial activities. In breast cancer cells, dimethoxycurcumin alters mitochondrial membrane potential, decreases ATP synthase activity, and induces DNA damage and apoptosis. In comparison to curcumin, dimethoxycurcumin is more stable and displays greater apoptosis-inducing activity in vitro. Additionally, dimethoxycurcumin is more effective in inhibition of NO production, iNOS expression, and NF-κB activation than curcumin. Dimethoxycurcumin exhibits pro-oxidative activity in cancer cells, increasing reactive oxygen species (ROS), but does not do so in normal cultured cells. This compound also inhibits the expression of pro-inflammatory cytokines such as IL-2, IL-6, and IFN-γ in vitro. Dimethoxycurcumin has phototoxic antibacterial activity against both gram-positive and gram-negative bacteria and binds the minor groove of DNA without intercalation.

Product Info

Cas No.

160096-59-3

Purity

≥98%

Formula

C23H24O6

Formula Wt.

396.43

Chemical Name

1,7-bis(3,4-dimethoxyphenyl)-1,6-heptadiene-3,5-dione

IUPAC Name

(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-1,6-heptadiene-3,5-dione

Synonym

Tetramethoxycurcumin

Appearance

Orange powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D3449 MSDS PDF

Info Sheet

D3449 Info Sheet PDF

Brochures

Curcumin Flyer

Natural Products Booklet

References

Kunwar A, Jayakumar S, Srivastava AK, et al. Dimethoxycurcumin-induced cell death in human breast carcinoma MCF7 cells: evidence for pro-oxidant activity, mitochondrial dysfunction, and apoptosis. Arch Toxicol. 2012 Apr;86(4):603-14. PMID: 22119759.

Patwardhan RS, Checker R, Sharma D, et al. Dimethoxycurcumin, a metabolically stable analogue of curcumin, exhibits anti-inflammatory activities in murine and human lymphocytes. Biochem Pharmacol. 2011 Sep 15;82(6):642-57. PMID: 21726543.

Kunwar A, Barik A, Sandur SK, et al. Differential antioxidant/pro-oxidant activity of dimethoxycurcumin, a synthetic analogue of curcumin. Free Radic Res. 2011 Aug;45(8):959-65. PMID: 21615275.

Kunwar A, Simon E, Singh U, et al. Interaction of a curcumin analogue dimethoxycurcumin with DNA. Chem Biol Drug Des. 2011 Apr;77(4):281-7. PMID: 21244640

Haukvik T, Bruzell E, Kristensen S, et al. A screening of curcumin derivatives for antibacterial phototoxic effects studies on curcumin and curcuminoids. XLIII. Pharmazie. 2011 Jan;66(1):69-74. PMID: 21391438.

Pae HO, Jeong SO, Kim HS, et al. Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS. Mol Nutr Food Res. 2008 Sep;52(9):1082-91. PMID: 18481332.

Tamvakopoulos C, Dimas K, Sofianos ZD, et al. Metabolism and anticancer activity of the curcumin analogue, dimethoxycurcumin. Clin Cancer Res. 2007 Feb 15;13(4):1269-77. PMID: 17317839.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E544766

    Enterocin

    A bacteriocin

    ≥95%
  • B3373

    Bis(aziridinyl)methylamino Phosphine Sulfide

    Insect sterilizer; mutagenic.

    ≥98%
  • E7357

    Esomeprazole Potassium

    (S) isomer of omeprazole; H+/K+ ATPase and MAO-...

    ≥98%
  • G6803

    Granuliberin R

    Antimicrobial peptide found in amphibians.

    ≥95%
  • T6831

    Triadimenol

    Triadimefon metabolite; mutagen.

    ≥96%
  • P1754

    Penciclovir

    Nucleoside (guanosine) analog; DNA chain termin...

    ≥98%
  • A0776

    ABT-199

    BH3 mimetic; Bcl-2 inhibitor.

    ≥99%
  • C0263

    L-Carnitine Hydrochloride

    Endogenous quaternary ammonium, required for fa...

    ≥98%
  • T0077

    Transactivator of Transcription Peptide (2-4)

    Peptide, contains two cell-penetrating sequence...

    ≥95%
  • K1677

    Ketoprofen

    NSAID; COX-1/2 and lactate dehydrogenase inhibi...

    ≥98%
  • D6957

    Droloxifene

    Triphenylthylene, tamoxifen analog; SERM.

    ≥98%
  • W4096

    WKYMVM-NH2

    Synthetic peptide; FPRL1 agonist.

    ≥95%
  • O9334

    Oxibendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥98%
  • H9711

    (Z)-4-Hydroxytamoxifen

    SERM.

    ≥98%
  • T1020

    n-Butyl Analog of Paclitaxel

    Fermentation impurity

    ≥95%
  • L283720

    Losartan Carboxylic acid

    Active metabolite of losartan

    ≥ 99%
  • A7210

    L-(+)-Ascorbic Acid

    Form of vitamin C found in various plant and fo...

    ≥98%
  • M5675

    Motilin, canine

    Endogenous peptide hormone; motilin agonist.

    ≥95%
  • E6396

    EPZ005687

    EZH2 HMT inhibitor.

    ≥99%
  • S8047

    R,S-Sulforaphane, Research Grade

    Synthetic ITC.

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only