• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Dimethoxycurcumin

Dimethoxycurcumin

Product ID D3449
Cas No. 160096-59-3
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $200.10 In stock
10 mg $306.20 In stock
25 mg $612.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Like its parent compound, curcumin, this curcuminoid exhibits anticancer, antioxidative, anti-inflammatory, and antibacterial activities. In breast cancer cells, dimethoxycurcumin alters mitochondrial membrane potential, decreases ATP synthase activity, and induces DNA damage and apoptosis. In comparison to curcumin, dimethoxycurcumin is more stable and displays greater apoptosis-inducing activity in vitro. Additionally, dimethoxycurcumin is more effective in inhibition of NO production, iNOS expression, and NF-κB activation than curcumin. Dimethoxycurcumin exhibits pro-oxidative activity in cancer cells, increasing reactive oxygen species (ROS), but does not do so in normal cultured cells. This compound also inhibits the expression of pro-inflammatory cytokines such as IL-2, IL-6, and IFN-γ in vitro. Dimethoxycurcumin has phototoxic antibacterial activity against both gram-positive and gram-negative bacteria and binds the minor groove of DNA without intercalation.

Product Info

Cas No.

160096-59-3

Purity

≥98%

Formula

C23H24O6

Formula Wt.

396.43

Chemical Name

1,7-bis(3,4-dimethoxyphenyl)-1,6-heptadiene-3,5-dione

IUPAC Name

(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-1,6-heptadiene-3,5-dione

Synonym

Tetramethoxycurcumin

Appearance

Orange powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D3449 MSDS PDF

Info Sheet

D3449 Info Sheet PDF

Brochures

Curcumin Flyer

Natural Products Booklet

References

Kunwar A, Jayakumar S, Srivastava AK, et al. Dimethoxycurcumin-induced cell death in human breast carcinoma MCF7 cells: evidence for pro-oxidant activity, mitochondrial dysfunction, and apoptosis. Arch Toxicol. 2012 Apr;86(4):603-14. PMID: 22119759.

Patwardhan RS, Checker R, Sharma D, et al. Dimethoxycurcumin, a metabolically stable analogue of curcumin, exhibits anti-inflammatory activities in murine and human lymphocytes. Biochem Pharmacol. 2011 Sep 15;82(6):642-57. PMID: 21726543.

Kunwar A, Barik A, Sandur SK, et al. Differential antioxidant/pro-oxidant activity of dimethoxycurcumin, a synthetic analogue of curcumin. Free Radic Res. 2011 Aug;45(8):959-65. PMID: 21615275.

Kunwar A, Simon E, Singh U, et al. Interaction of a curcumin analogue dimethoxycurcumin with DNA. Chem Biol Drug Des. 2011 Apr;77(4):281-7. PMID: 21244640

Haukvik T, Bruzell E, Kristensen S, et al. A screening of curcumin derivatives for antibacterial phototoxic effects studies on curcumin and curcuminoids. XLIII. Pharmazie. 2011 Jan;66(1):69-74. PMID: 21391438.

Pae HO, Jeong SO, Kim HS, et al. Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS. Mol Nutr Food Res. 2008 Sep;52(9):1082-91. PMID: 18481332.

Tamvakopoulos C, Dimas K, Sofianos ZD, et al. Metabolism and anticancer activity of the curcumin analogue, dimethoxycurcumin. Clin Cancer Res. 2007 Feb 15;13(4):1269-77. PMID: 17317839.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G7241

    GSK-461364

    PLK1 inhibitor.

    ≥99%
  • D3227

    Dihydromethysticin

    Kavalactone originally found in Piper methystic...

    ≥97%
  • L0108

    Lacidipine

    Calcium channel blocker.

    ≥98%
  • G0248

    (-)-Gambogic Acid

    Xanthone found in Garcinia hanburyi.

    ≥99%
  • H2980

    Humanin, human

    Endogenous peptide; FPRL1/2 agonist.

    ≥95%
  • N344784

    N-Nitroso Valsartan

    Valsartan impurity

    ≥98%
  • R2712

    Recombinant HCV-NS3 Antigens

    Recombinant HCV antigen fragment.

    ≥95%
  • C002041

    Cabazitaxel

    Taxoid that disrupts the microtubular network i...

    ≥98%
  • R3011

    Recombinant TpN 15 protein

    Recombinant protein containing Treponema pallid...

    ≥95%
  • H9615

    17α-Hydroxyprogesterone Caproate

    Synthetic steroid hormone; ER antagonist.

    ≥98%
  • A4521

    Alfacalcidol

    Vitamin D analog.

    ≥98%
  • S824766

    Sutezolid

    Bactericidal.

    ≥98%
  • A0916

    Acepromazine Maleate

    Phenothiazine derivative; D1/2 and 5-HT1A/2A an...

    ≥99%
  • G3358

    Ginkgolide ABC

    Mixture of Ginkgolides A, B and C, found in Gin...

    ≥98%
  • H174466

    Helvolic acid

    A fungal metabolite that inhibits protein synth...

    ≥98%
  • G7345

    GSK-2606414

    PERK inhibitor.

    ≥99%
  • S9754

    Syntide 2

    Synthetic peptide, CDPK, PKC, CaMKII substrate....

    ≥95%
  • B4796

    BLZ-945

    CSF-1R Inhibitor.

    ≥95%
  • C2943

    Chlorogenic Acid (from Eucommia)

    Polyphenol derivative of caffeic acid found in ...

    ≥98%
  • D3221

    Difluoromethylornithine Hydrochloride Monohydrate

    Ornithine decarboxylase inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only