• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Diosmetin

Diosmetin

Product ID D3356
Cas No. 520-34-3
Purity ≥98%
Product Unit SizeCostQuantityStock
250 mg $132.60 In stock
1 g $355.00 In stock
5 g $874.90 In stock
25 g $2,734.60 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Diosmetin is an O-methylated flavone found in vetch and various citrus fruits; it exhibits antioxidative, anti-inflammatory, anticancer, and anti-osteoporotic activities. In animal models of AAPH-induced oxidative stress, diosmetin decreases generation of ROS and increases levels of superoxide dismutase, catalase, and glutathione peroxidase. Diosmetin also decreases amylase, lipase, TNF-α, IL-1β, IL-6, and iNOS in animal models of pancreatitis. In breast cancer cells, diosmetin induces G1 phase cell cycle arrest and inhibits cellular proliferation. Additionally, this compound increases activation of PKC, ERK1/2, and p38 MAPK, inducing osteoblastic differentiation in vitro.

Product Info

Cas No.

520-34-3

Purity

≥98%

Formula

C16H12O6

Formula Wt.

300.26

Chemical Name

benzopyran-4-one

IUPAC Name

5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one

Synonym

Cyanidenon-4'-methyl ether 1479, Luteolin-4'-methyl ether

Melting Point

257-259°C

Solubility

Sparingly soluble in water (<1 mg/ml). Soluble in acetonitrile, DMSO (60 mg/ml), and ethanol (17 mg/ml).

Appearance

Yellow Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D3356 MSDS PDF

Info Sheet

D3356 Info Sheet PDF

References

Liao W, Ning Z, Chen L, et al. Intracellular Antioxidant Detoxifying Effects of Diosmetin on 2,2-Azobis(2-amidinopropane) Dihydrochloride (AAPH)-Induced Oxidative Stress through Inhibition of Reactive Oxygen Species Generation. J Agric Food Chem. 2014 Aug 27;62(34):8648-54. PMID: 25075433.

Yu G, Wan R, Yin G, et al. Diosmetin ameliorates the severity of cerulein-induced acute pancreatitis in mice by inhibiting the activation of the nuclear factor-κB. Int J Clin Exp Pathol. 2014 Apr 15;7(5):2133-42. PMID: 24966921.

Androutsopoulos VP, Mahale S, Arroo RR, et al. Anticancer effects of the flavonoid diosmetin on cell cycle progression and proliferation of MDA-MB 468 breast cancer cells due to CYP1 activation. Oncol Rep. 2009 Jun;21(6):1525-8. PMID: 19424633.

Hsu YL, Kuo PL. Diosmetin induces human osteoblastic differentiation through the protein kinase C/p38 and extracellular signal-regulated kinase 1/2 pathway. J Bone Miner Res. 2008 Jun;23(6):949-60. PMID: 18269307.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S8009

    Substance P (7-11)

    Endogenous tachykinin peptide, involved in infl...

    ≥95%
  • M1979

    Methyl Salicylate

    Ester found in Spiraea, Betula, and Gaultheria;...

    ≥98%
  • I4962

    Isoimperatorin

    Furocoumarin; COX-2 inhibitor.

    ≥98%
  • C0167

    Carbenoxolone

    Synthetic glycyrrhetinic acid derivative; 11β-...

    ≥98%
  • R5774

    Roscovitine

    CDK inhibitor, L-type Ca2+ channel blocker.

    ≥98%
  • I7457

    1-Isothiocyanato-6-(methylsulfinyl)-hexane

    Synthetic derivative of 6-methylsulfinyl-hexane...

    ≥98%
  • D5610

    Docosahexaenoic Acid (all cis-4,7,10,13,16,19)

    Essential fatty acid found in fish oil, involve...

    ≥98%
  • T6811

    Tranexamic Acid

    Plasminogen inhibitor.

    ≥98%
  • A5133

    Amiloride Hydrochloride Dihydrate

    K+-sparing diuretic; ENaC and acid-sensing ion ...

    ≥98%
  • G1210

    GDC-0623

    MEK inhibitor.

    ≥98%
  • B560000

    RAD51 inhibitor, B02

    RAD51 inhibitor.

    ≥98%
  • S4244

    SKLB 610

    VEGFR2, PDGFR, FGFR2 inhibitor.

    ≥98%
  • L1780

    Levocetirizine Dihydrochloride

    L-isomer of cetirizine; histamine H1 antagonist...

    ≥98%
  • C0171

    Carboplatin

    Pt-based DNA cross-linker.

    ≥99%
  • V024761

    Vatalanib

    Inhibitor of VEGFR1/2/3.

    ≥98%
  • O4402

    Olaparib

    PARP1/2 inhibitor.

    ≥98%
  • B1753

    Benfotiamine

    Thiamine/vitamin B derivative, antioxidant.

    ≥98%
  • J974440

    JZL184

    MAGL inhibitor.

    ≥98%
  • K0088

    Kawain

    Kavalactone originally found in Piper methystic...

    ≥98%
  • P6858

    Procarbazine Hydrochloride

    Hydrazine derivative, DNA alkylator; MAO inhibi...

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only