Elcatonin Acetate

Description

Elcatonin is a synthetic analog of eel calcitonin that exhibits analgesic, anti-allodynic, antacid, and anti-resorptive activities. In animal models, elcatonin inhibits the effects of thermal and mechanical pain; it also decreases hyperalgesia induced by chronic constrictive injury. When administered clinically, elcatonin decreases symptoms of gastroesophageal reflux disease (GERD), such as heartburn and acid reflux. Additionally, this peptide induces osteoblast proliferation and prevents bone resorption and decreases in bone mineral density in animal models of bone injury.

Product Info

Cas No.	60731-46-6
Purity	≥95%
Formula	C₁₄₈H₂₄₄N₄₂O₄₇
Formula Wt.	3363.8

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

Info Sheet	E4408 Info Sheet PDF

References

Aoki M, Kurauchi Y, Mori A, et al. Comparison of the effects of single doses of elcatonin and pregabalin on oxaliplatin-induced cold and mechanical allodynia in rats. Biol Pharm Bull. 2014;37(2):322-6. PMID: 24492729.

Ito A, Takeda M, Yoshimura T, et al. Anti-hyperalgesic effects of calcitonin on neuropathic pain interacting with its peripheral receptors. Mol Pain. 2012 Jun 7;8:42. PMID: 22676202.

Yamane Y, Yamaguchi T, Tsumori M, et al. Elcatonin is effective for lower back pain and the symptoms of gastroesophageal reflux disease in elderly osteoporotic patients with kyphosis. Geriatr Gerontol Int. 2011 Apr;11(2):215-20. PMID: 21199237.

Katae Y, Tanaka S, Sakai A, et al. Elcatonin injections suppress systemic bone resorption without affecting cortical bone regeneration after drill-hole injuries in mice. J Orthop Res. 2009 Dec;27(12):1652-8. PMID: 19489046.

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