Description
Entacapone is an inhibitor of catechol-O-methyltransferase (COMT), an enzyme responsible for metabolism of dopamine. Entacapone is commonly used to treat Parkinson’s disease and is given with L-DOPA as it reduces clearance of L-DOPA and improves motor function. Entacapone also displays other neuroprotective benefit, particularly in models of Alzheimer’s disease; it prevents α-synuclein and amyloid-β (Aβ) oligomerization and fibril formation. This compound decreases striatal homovanillic acid levels.