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Exendin 3 (9-39) is a gastrointestinal motility modulating peptide fragment of exendin-3. This peptide acts as an antagonist at glucagon-like peptide 1 (GLP-1) receptors, increasing spontaneous contractions in colon circular muscle. This peptide inhibits the effects of exendin-4 and other GLP-1 agonists. Exendin-3 was originally found in Heloderma lizards.
| Cas No. | 133514-43-9 |
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| Purity | ≥95% |
| Formula | C149H234N40O47S |
| Formula Wt. | 3369.83 |
| Synonym | 9-39-Exendin 3(Heloderma horridum) (9CI), Exendin 3 (9-39) |
| Solubility | Soluble in water (1 mg/mL), DMSO. |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
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| Info Sheet |
Amato A, Baldassano S, Liotta R, et al. Exogenous glucagon-like peptide-1 reduces contractions in human colon circular muscle. J Endocrinol. 2014 Jan 17. [Epub ahead of print]. PMID: 24443715.
Hu G, Zhang Y, Jiang H, et al. Exendin-4 attenuates myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein expression. Cardiol J. 2013;20(6):600-4. PMID: 24338536.