Description
Galanin is an endogenous neuropeptide that binds GAL receptors and is involved in action potential signaling and propagation in neurons. Galanin exhibits anticonvulsant/antiepileptic activity, inhibiting glutamate and suppressing seizures. Galanin also inhibits insulin secretion and plays a role in nociception, sleep regulation, cognition, feeding, blood pressure, and mood. Galanin displays both neuroprotective and neurotoxic activities, as galanin expression is increased in the brain tissue of Alzheimer’s disease patients; it is also involved in modulation of cholinergic signaling.