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GDC-0879

GDC-0879

Product ID G1208
Cas No. 905281-76-7
Purity ≥96%
Product Unit SizeCostQuantityStock
1 mg $97.20 Please Inquire
5 mg $359.90 Please Inquire
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

GDC-0879 is an orally bioavailable kinase inhibitor that exhibits anticancer chemotherapeutic activity in vitro and in vivo. GDC-0879 inhibits mutant (V600E) B-Raf, a mutation common to many types of cancer. This inhibition of mutant B-Raf decreases MEK1 phosphorylation, downregulating expression of genes associated with cell proliferation and resulting in sustained inhibition of tumor cell proliferation.

Product Info

Cas No.

905281-76-7

Purity

≥96%

Formula

C19H18N4O2

Formula Wt.

334.37

Chemical Name

(E)-5-(1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydroinden-1-one oxime

IUPAC Name

2-[4-[(1E)-1-hydroxyimino-2, 3-dihydroinden-5-yl]-3-pyridin-4-ylpyrazol-1-yl]ethanol

Solubility

DMSO 66 mg/mL warmed (197.38 mM) Ethanol 5 mg/mL (14.95 mM) Water Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G1208 MSDS PDF

Info Sheet

G1208 Info Sheet PDF

Brochures

Ras-Raf-MEK-ERK Pathway Booklet

References

Hoeflich KP, Herter S, Tien J, et al. Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression. Cancer Res. 2009 Apr 1;69(7):3042-51. PMID: 19276360.

Wong H, Belvin M, Herter S, et al. Pharmacodynamics of 2-[4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridine-4-yl)-1H-pyrazol-1-yl]ethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor: understanding relationships between systemic concentrations, phosphorylated mitogen-activated protein kinase kinase 1 inhibition, and efficacy. J Pharmacol Exp Ther. 2009 Apr;329(1):360-7. PMID: 19147858.

Custom Order

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