LKT Labs

Biochemicals for Life Science Research

Ginsenoside Rc

Product ID G3455
Cas No. 11021-14-0
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $117.70 In stock
5 mg $294.40 In stock
10 mg $515.20 In stock
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Description

Ginsenoside Rc is a triterpene saponin originally found in species of Panax that exhibits antioxidative, anti-aging, antinociceptive, and anti-diabetic activities. Ginsenoside Rc inhibits phosphorylation of Foxo1, inhibits AMPK, activates PI3K/Akt signaling, and increases levels of catalase, decreasing oxidative stress. Ginsenoside Rc also induces antinociception in animal models of writhing and formalin-induced pain, potentially through activity on transient receptor potential vanilloid 1 (TRPV1) channels. In other animal models, ginsenoside Rc activates AMPK and p38 MAPK, increasing glucose uptake. Additionally, this compound increases the life span of Caenorhabditis elegans.

Product Info

Cas No.

11021-14-0
Purity

≥98%
Formula

C53H90O22
Formula Wt.

1079.27
IUPAC Name

2-[2-[[17-[2-[6-[[3, 4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxymethyl]-3,4, 5-trihydroxyoxan-2-yl]oxy-6-methylhept-5-en-2-yl]-12-hydroxy-4,4,8,10, 14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16, 17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-4, 5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4, 5-triol
Synonym

Panaxoside RC
Appearance

White powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

G3455 MSDS PDF
Info Sheet

G3455 Info Sheet PDF

References

Kim DH, Park CH, Park D, et al. Ginsenoside Rc modulates Akt/FoxO1 pathways and suppresses oxidative stress. Arch Pharm Res. 2014 Jun;37(6):813-20. PMID: 23918648.

Lee MS, Hwang JT, Kim SH, et al. Ginsenoside Rc, an active component of Panax ginseng, stimulates glucose uptake in C2C12 myotubes through an AMPK-dependent mechanism. J Ethnopharmacol. 2010 Feb 17;127(3):771-6. PMID: 19961916.

Lee JH, Choi SH, Kwon OS, et al. Effects of ginsenosides, active ingredients of Panax ginseng, on development, growth, and life span of Caenorhabditis elegans. Biol Pharm Bull. 2007 Nov;30(11):2126-34. PMID: 17978487.

Jung SY, Choi S, Ko YS, et al. Effects of ginsenosides on vanilloid receptor (VR1) channels expressed in Xenopus oocytes. Mol Cells. 2001 Dec 31;12(3):342-6. PMID: 11804333.

Shin YH, Jung OM, Nah JJ, et al. Ginsenosides that produce differential antinociception in mice. Gen Pharmacol. 1999 Jun;32(6):653-9. PMID: 10401990.

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