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Gliclazide

Gliclazide

Product ID G4532
Cas No. 21187-98-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $66.40 In stock
5 g $128.60 In stock
10 g $214.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Gliclazide is a sulfonylurea compound that inhibits sulfonylurea 1 (SUR1) receptors, exhibiting anti-diabetic and antioxidative activities. Inhibition of these receptors closes K+ ion channels, inducing cell membrane depolarization, altering Ca2+ homeostasis, and stimulating insulin release. In vitro, gliclazide inhibits H2O2-induced mitochondrial damage and apoptosis, decreasing oxidative stress.

Product Info

Cas No.

21187-98-4

Purity

≥98%

Formula

C15H21N3O3S

Formula Wt.

323.41

Chemical Name

N-[[(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)amino]- carbonyl]-4-methylbenzenesulfonamide

IUPAC Name

1-(3,3a,4,5,6, 6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea

Synonym

Diamicron, Glimicron, Nordialex

Melting Point

180-182°C

Solubility

Insoluble in water. Soluble in dichloromethane, chloroform, methanol, DMSO.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

G4532 MSDS PDF

Info Sheet

G4532 Info Sheet PDF

References

Proks P, de Wet H, Ashcroft FM. Molecular mechanism of sulphonylurea block of K(ATP) channels carrying mutations that impair ATP inhibition and cause neonatal diabetes. Diabetes. 2013 Nov;62(11):3909-19. PMID: 23835339.

Sliwinska A, Rogalska A, Szwed M, et al. Gliclazide may have an antiapoptotic effect related to its antioxidant properties in human normal and cancer cells. Mol Biol Rep. 2012 May;39(5):5253-67. PMID: 22183301.

Lawrence CL, Proks P, Rodrigo GC, et al. Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells. Diabetologia. 2001 Aug;44(8):1019-25. PMID: 11484080.

Custom Order

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