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Gliclazide is a sulfonylurea compound that inhibits sulfonylurea 1 (SUR1) receptors, exhibiting anti-diabetic and antioxidative activities. Inhibition of these receptors closes K+ ion channels, inducing cell membrane depolarization, altering Ca2+ homeostasis, and stimulating insulin release. In vitro, gliclazide inhibits H2O2-induced mitochondrial damage and apoptosis, decreasing oxidative stress.
| Cas No. | 21187-98-4 |
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| Purity | ≥98% |
| Formula | C15H21N3O3S |
| Formula Wt. | 323.41 |
| Chemical Name | N-[[(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)amino]- carbonyl]-4-methylbenzenesulfonamide |
| IUPAC Name | 1-(3,3a,4,5,6, 6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea |
| Synonym | Diamicron, Glimicron, Nordialex |
| Melting Point | 180-182°C |
| Solubility | Insoluble in water. Soluble in dichloromethane, chloroform, methanol, DMSO. |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Proks P, de Wet H, Ashcroft FM. Molecular mechanism of sulphonylurea block of K(ATP) channels carrying mutations that impair ATP inhibition and cause neonatal diabetes. Diabetes. 2013 Nov;62(11):3909-19. PMID: 23835339.
Sliwinska A, Rogalska A, Szwed M, et al. Gliclazide may have an antiapoptotic effect related to its antioxidant properties in human normal and cancer cells. Mol Biol Rep. 2012 May;39(5):5253-67. PMID: 22183301.
Lawrence CL, Proks P, Rodrigo GC, et al. Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells. Diabetologia. 2001 Aug;44(8):1019-25. PMID: 11484080.