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Helospectin I is a peptide originally found in Heloderma lizards. Helospectin I is a neuropeptide of the vasoactive intestinal peptide (VIP) family that exhibits vasodilatory and antihypertensive activities, decreasing blood pressure in vivo. Additionally, helospectin I increases plasma glucagon in animal models.
| Cas No. | 93438-37-0 |
|---|---|
| Purity | ≥95% |
| Formula | C183H293N47O59 |
| Formula Wt. | 4095.66 |
| Synonym | Exendin 1 |
| Solubility | Soluble in water. |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet |
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Tsueshita T, Onyükusel H, Sethi V, et al. Helospectin I and II evoke vasodilation in the intact peripheral microcirculation. Peptides. 2004 Jan;25(1):65-9. PMID: 15003357.
Uddman R, Goadsby PJ, Jansen-Olesen I, et al. Helospectin-like peptides: immunochemical localization and effects on isolated cerebral arteries and on local cerebral blood flow in the cat. J Cereb Blood Flow Metab. 1999 Jan;19(1):61-7. PMID: 9886356.
Ahrén B. Effects of helospectin I on insulin and glucagon secretion in the mouse. Br J Pharmacol. 1991 Apr;102(4):916-8. PMID: 1855119.
Grundemar L, Högestätt ED. Vascular effects of helodermin, helospectin I and helospectin II: a comparison with vasoactive intestinal peptide (VIP). Br J Pharmacol. 1990 Mar;99(3):526-8. PMID: 2331581.
