LKT Labs

Biochemicals for Life Science Research

[His18]-Amylin, rat

[His18]-Amylin, rat

Product ID A4850
Cas No.
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $313.00 In stock
1 mg $532.00 In stock
2.5 mg $940.00 In stock
Bulk Quote

Quicklinks

Description

Amylin is also known as islet amyloid precursor peptide (IAPP) and is co-secreted with insulin from pancreatic β-cells. Amylin is an endogenous peptide hormone that exhibits gastrointestinal motility modulating activity, decreasing gastric emptying and suppressing gastric acid secretion; these actions slow food intake, preventing blood glucose spikes after eating and decreasing insulin demand. Misguided IAPP processing plays a significant role in the development of diabetes mellitus type 2. Like calcitonin, IAPP inhibits osteoclast activity and Ca2+ reabsorption in bones. This peptide binds to calcitonin-RAMP complexes.

Product Info

Purity

≥95%
Formula

C167H267N51O53S2
Formula Wt.

3901.43
Synonym

IAPP, islet amyloid precursor peptide
Solubility

Soluble in water.
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A4850 MSDS PDF
Info Sheet

A4850 Info Sheet PDF

References

Paulsson JF, Westermark GT. Aberrant processing of human proislet amyloid polypeptide results in increased amyloid formation. Diabetes. 2005 Jul;54(7):2117-25. PMID: 15983213.

Ratner RE, Dickey R, Fineman M, et al. Amylin replacement with pramlintide as an adjunct to insulin therapy improves long-term glycaemic and weight control in Type 1 diabetes mellitus: a 1-year, randomized controlled trial. Diabet Med. 2004 Nov;21(11):1204-12. PMID: 15498087.

Pittner RA, Albrandt K, Beaumont K, et al. Molecular physiology of amylin. J Cell Biochem. 1994;55 Suppl:19-28. PMID: 7929615.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L1616

    LEE-011

    CDK4/6 inhibitor.

    ≥98%
  • P982691

    Pyridostatin Trifluoroacetate Salt

    G-quadruplex ligand; DNA breakage inducer.

    ≥95%
  • K1655

    Kenpaullone

    GSK-3β, HGK, and CDK inhibitor.

    ≥95%
  • C9613

    Cyclosporin D

    Cyclosporin metabolite; weak calmodulin inhibit...

    ≥98%
  • T0081

    Taurine

    Endogenous sulfonic acid involved in Ca2+ signa...

    ≥99%
  • T3099

    Thymus Factor

    Endogenous peptide, involved in immune signalin...

    ≥95%
  • N3228

    Nifedipine

    Dihydropyridine; L-type Ca2+ channel blocker.

    ≥98%
  • T1672

    Terbinafine Hydrochloride

    Allylamine; squalene oxidase and KSR1 inhibitor...

    ≥98%
  • B3275

    Bis(3,5-dibromosalicyl) Succinate

    Aspirin analog; hemoglobin chain cross-linker.<...

    ≥95%
  • V1745

    Veliparib

    PARP inhibitor.

    ≥99%
  • T1979

    Tetrahydrocoptisine

    Alkaloid compound originally found in Corydalis...

    ≥98%
  • S9775

    Systemin

    Peptide hormone found in Solanaceae family plan...

    ≥95%
  • S6018

    Spectinomycin Dihydrochloride Pentahydrate

    Aminocyclitol; protein synthesis inhibitor.

    ≥603 µg/mg (potency)
  • F3454

    Fingolimod Hydrochloride

    Sphingosine 1-phosphate antagonist.

    ≥99%
  • P2995

    Physcion

    Anthraquinone found in various plant sources.

    ≥96%
  • T3098

    Thymosin β-4 Acetate

    Endogenous peptide; actin polymerization inhibi...

    ≥95%
  • C0020

    Cafestol

    Diterpene found in brewed, unfiltered coffee; F...

    ≥98%
  • F1607

    Febuxostat

    Xanthine oxidase inhibitor.

    ≥98%
  • T1655

    Tenoxicam Impurity 1

    Tenoxicam impurity

    ≥98%
  • O7218

    Oseltamivir Phosphate

    Viral neuraminidase inhibitor, potential MAO-A ...

    ≥98%