LKT Labs

Biochemicals for Life Science Research

[His18]-Amylin, rat

[His18]-Amylin, rat

Product ID A4850
Cas No.
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $313.00 In stock
1 mg $532.00 In stock
2.5 mg $940.00 In stock
Bulk Quote

Quicklinks

Description

Amylin is also known as islet amyloid precursor peptide (IAPP) and is co-secreted with insulin from pancreatic β-cells. Amylin is an endogenous peptide hormone that exhibits gastrointestinal motility modulating activity, decreasing gastric emptying and suppressing gastric acid secretion; these actions slow food intake, preventing blood glucose spikes after eating and decreasing insulin demand. Misguided IAPP processing plays a significant role in the development of diabetes mellitus type 2. Like calcitonin, IAPP inhibits osteoclast activity and Ca2+ reabsorption in bones. This peptide binds to calcitonin-RAMP complexes.

Product Info

Purity

≥95%
Formula

C167H267N51O53S2
Formula Wt.

3901.43
Synonym

IAPP, islet amyloid precursor peptide
Solubility

Soluble in water.
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A4850 MSDS PDF
Info Sheet

A4850 Info Sheet PDF

References

Paulsson JF, Westermark GT. Aberrant processing of human proislet amyloid polypeptide results in increased amyloid formation. Diabetes. 2005 Jul;54(7):2117-25. PMID: 15983213.

Ratner RE, Dickey R, Fineman M, et al. Amylin replacement with pramlintide as an adjunct to insulin therapy improves long-term glycaemic and weight control in Type 1 diabetes mellitus: a 1-year, randomized controlled trial. Diabet Med. 2004 Nov;21(11):1204-12. PMID: 15498087.

Pittner RA, Albrandt K, Beaumont K, et al. Molecular physiology of amylin. J Cell Biochem. 1994;55 Suppl:19-28. PMID: 7929615.

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