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Hyaluronic acid is an endogenous anionic non-sulfated glycosaminoglycan that is found in connective tissue, epithelial tissue, and synovial fluid. Hyaluronic acid exhibits pro-inflammatory activity, binding surface proteins CD44, RHAMM, and ICAM-1. Hyaluronic acid is often used as a biomarker for cancers and fibrosis. (Streptococcus)
| Cas No. | 9067-32-7 |
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| Formula | (C14H20NO11Na)n |
| Formula Wt. | ~1,000,000 |
| Chemical Name | Hyaluronic Acid Sodium |
| IUPAC Name | sodium;(2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-acetamido-2-[(2S,3S,4R,5R, 6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2, 5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4, 5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4, 5-trihydroxyoxane-2-carboxylic acid |
| Synonym | ARTZ, Equron, Healon, Hyalgan, Ial, Provisc, Synacid |
| Solubility | Soluble in water (5mg/mL) up to 1%. In ice-water it will dissolve faster, may take 24 hours to be transparent. |
| Appearance | White to off white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Chen B, Miller RJ, Dhal PK. Hyaluronic acid-based drug conjugates: state-of-the-art and perspectives. J Biomed Nanotechnol. 2014 Jan;10(1):4-16. PMID: 24724495.
Rostami S, Parsian H. Hyaluronic Acid: from biochemical characteristics to its clinical translation in assessment of liver fibrosis. Hepat Mon. 2013 Dec 14;13(12):e13787. PMID: 24403913.
Yung S, Cheung KF, Zhang Q, et al. Mediators of inflammation and their effect on resident renal cells: implications in lupus nephritis. Clin Dev Immunol. 2013;2013:317682. PMID: 24171032.
Josefsson A, Adamo H, Hammarsten P, et al. Prostate cancer increases hyaluronan in surrounding nonmalignant stroma, and this response is associated with tumor growth and an unfavorable outcome. Am J Pathol. 2011 Oct;179(4):1961-8. PMID: 21854754.
Toole BP. Hyaluronan is not just a goo! J Clin Invest. 2000 Aug;106(3):335-6. PMID: 10930435.