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Hydroxyzine Dihydrochloride

Hydroxyzine Dihydrochloride

Product ID H9717
Cas No. 2192-20-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $61.10 In stock
5 g $88.30 In stock
10 g $141.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Hydroxyzine is a first generation antihistamine that acts as an inverse agonist at histamine H1 receptors. Hydroxyzine exhibits anti-allergic, antipsychotic, anxiolytic, and sedative activities; it is the parent compound of cetirizine. Hydroxyzine also inhibits 5-HT2A, D1/2, and α1-adrenergic receptors and acts as a functional inhibitor of acid sphingomyelinase (FIASMA).

 

Product Info

Cas No.

2192-20-3

Purity

≥98%

Formula

C21H27ClN2O2 • 2HCl

Formula Wt.

447.83

Chemical Name

Ethanol, 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1- piperazinyl)ethoxy)-, dihydrochloride

IUPAC Name

2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol; dihydrochloride

Synonym

Alamon, Atarax, Aterax, Durrax, Orgatrax, Quiess, Vistaril Parental.

Melting Point

193°C

Solubility

Soluble in water (<700mg/mL), ethanol (220 mg/mL), chloroform (60mg/mL) or acetone (2mg/mL).

Appearance

White of almost white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

H9717 MSDS PDF

Info Sheet

H9717 Info Sheet PDF

References

Llorca PM, Spadone C, Sol O, et al. Efficacy and safety of hydroxyzine in the treatment of generalized anxiety disorder: a 3-month double-blind study. J Clin Psychiatry. 2002 Nov;63(11):1020-7. PMID: 12444816.

Minogiannis P, El-Mansoury M, Betances JA, et al. Hydroxyzine inhibits neurogenic bladder mast cell activation. Int J Immunopharmacol. 1998 Oct;20(10):553-63. PMID: 9839659.

Haraguchi K, Ito K, Kotaki H, et al. Prediction of drug-induced catalepsy based on dopamine D1, D2, and muscarinic acetylcholine receptor occupancies. Drug Metab Dispos. 1997 Jun;25(6):675-84. PMID: 9193868.

Snowman AM, Snyder SH. Cetirizine: actions on neurotransmitter receptors. J Allergy Clin Immunol. 1990 Dec;86(6 Pt 2):1025-8. PMID: 1979798.

Custom Order

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