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Hypaconitine is a diterpene alkaloid originally found in Aconitum that acts as a neuromuscular junction blocker. Hypaconitine inhibits end plate potentials in isolated phrenic nerve-diaphragm muscles. Hypaconitine induces long-term opening of Na+ channels, causing membrane depolarization and preventing repolarization.
| Cas No. | 6900-87-4 |
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| Purity | ≥90% |
| Formula | C33H45NO10 |
| Formula Wt. | 615.71 |
| Chemical Name | 16,16-trimethoxy-4-(methoxymethyl)-20-methyl- 8-acetatebenzoate-(1-alpha,6-alpha,14-alpha,15-alpha,16-beta)-Aconitane-8,13,14,15-tetraol |
| IUPAC Name | [(1S,2R,3R,4R,5R,6S,7S,8R,9R,13S,16S,17R,18R)-8-acetyloxy-5,7-dihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-methyl-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate |
| Synonym | Japaconitine C, Deoxymesaconitine |
| Appearance | White crystalline powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Muroi M, Kimura I, Kimura M. Blocking effects of hypaconitine and aconitine on nerve action potentials in phrenic nerve-diaphragm muscles of mice. Neuropharmacology. 1990 Jun;29(6):567-72. PMID: 2385329.
Kimura M, Muroi M, Kimura I, et al. Hypaconitine, the dominant constituent responsible for the neuromuscular blocking action of the Japanese-sino medicine "bushi" (aconite root). Jpn J Pharmacol. 1988 Oct;48(2):290-3. PMID: 3210453.