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Hypaconitine

Hypaconitine

Product ID H9759
Cas No. 6900-87-4
Purity ≥90%
Product Unit SizeCostQuantityStock
10 mg $220.80 In stock
25 mg $410.30 In stock
100 mg $1,262.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Hypaconitine is a diterpene alkaloid originally found in Aconitum that acts as a neuromuscular junction blocker. Hypaconitine inhibits end plate potentials in isolated phrenic nerve-diaphragm muscles. Hypaconitine induces long-term opening of Na+ channels, causing membrane depolarization and preventing repolarization.

Product Info

Cas No.

6900-87-4

Purity

≥90%

Formula

C33H45NO10

Formula Wt.

615.71

Chemical Name

16,16-trimethoxy-4-(methoxymethyl)-20-methyl- 8-acetatebenzoate-(1-alpha,6-alpha,14-alpha,15-alpha,16-beta)-Aconitane-8,13,14,15-tetraol

IUPAC Name

[(1S,2R,3R,4R,5R,6S,7S,8R,9R,13S,16S,17R,18R)-8-acetyloxy-5,7-dihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-methyl-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate

Synonym

Japaconitine C, Deoxymesaconitine

Appearance

White crystalline powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

H9759 MSDS PDF

Info Sheet

H9759 Info Sheet PDF

References

Muroi M, Kimura I, Kimura M. Blocking effects of hypaconitine and aconitine on nerve action potentials in phrenic nerve-diaphragm muscles of mice. Neuropharmacology. 1990 Jun;29(6):567-72. PMID: 2385329.

Kimura M, Muroi M, Kimura I, et al. Hypaconitine, the dominant constituent responsible for the neuromuscular blocking action of the Japanese-sino medicine "bushi" (aconite root). Jpn J Pharmacol. 1988 Oct;48(2):290-3. PMID: 3210453.

Custom Order

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