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Hyperforin Dicyclohexylammonium

Hyperforin Dicyclohexylammonium

Product ID H9863
Cas No. 238074-03-8
Purity ≥97%
Product Unit SizeCostQuantityStock
500 µg $306.20 In stock
1 mg $501.30 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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  • Downloads
  • References
  • Custom Order

Description

Hyperforin DCHA is a stable salt form of hyperforin, a compound found in Hypericum perforatum (St. John’s Wort). Hyperforin DCHA exhibits anticancer, anti-inflammatory, and antidepressant activities. In chronic myelogenous leukemia (CML) cells, hyperforin DCHA disrupts the mitochondrial membrane potential, increases release of cytochrome c, activates caspases 3, 8, and 9, and induces cleavage of poly(ADP)-ribose polymerase (PARP), resulting in G1 phase cell cycle arrest and apoptosis. In astrocytoma cells, hyperforin DCHA prevents LPS- and substance P-induced release of IL-6. In animal models, this compound prevents croton oil-induced edema. Additionally, hyperforin DCHA decreases immobility time in animals undergoing the forced swim test.

Product Info

Cas No.

238074-03-8

Purity

≥97%

Formula

C35H52O4 • C12H23N

Formula Wt.

718.10

IUPAC Name

N-cyclohexylcyclohexanamine;(1R,5R,6R,7S)-2-hydroxy-6-methyl-1,3,7-tris(3-methylbut-2-enyl)-6-(4-methylpent-3-enyl)-5-(2-methylpropanoyl)bicyclo[3.3.1]non-2-ene-4,9-dione

Synonym

Hyperforin DCHA

Solubility

Soluble in DMSO (≥10 mg/ml), methanol, and 100% ethanol

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

H9863 MSDS PDF

Info Sheet

H9863 Info Sheet PDF

References

Liu JY, Liu Z, Wang DM, et al. Induction of apoptosis in K562 cells by dicyclohexylammonium salt of hyperforin through a mitochondrial-related pathway. Chem Biol Interact. 2011 Apr 25;190(2-3):91-101. PMID: 21376709.

Sosa S, Pace R, Bornancin A, et al. Topical anti-inflammatory activity of extracts and compounds from Hypericum perforatum L. J Pharm Pharmacol. 2007 May;59(5):703-9. PMID: 17524236.

Gobbi M, Moia M, Funicello M, et al. In vitro effects of the dicyclohexylammonium salt of hyperforin on interleukin-6 release in different experimental models. Planta Med. 2004 Jul;70(7):680-2. PMID: 15303261.

Cervo L, Rozio M, Ekalle-Soppo CB, et al. Role of hyperforin in the antidepressant-like activity of Hypericum perforatum extracts. Psychopharmacology (Berl). 2002 Dec;164(4):423-8. PMID: 12457273.

Custom Order

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