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Hypocrellin B exhibits antibacterial, anti-metastatic, and anticancer chemotherapeutic activities. Hypocrellin B inhibits proliferation of Staphylococcus by increasing ROS levels and damaging cell walls. In ovarian cancer cells, this compound induces apoptosis and inhibits cell migration and adhesion under photodynamic stimulation; it also induces tumor regression in animal models of lymphoma. In vitro, hypocrellin B induces DNA strand breakage.
Contains ~2.5 % hypocrellin A.
| Cas No. | 123940-54-5 |
|---|---|
| Purity | ≥98% |
| Formula | C30H24O9 |
| Formula Wt. | 528.51 |
| IUPAC Name | 12-acetyl-9,17-dihydroxy-5,10,16,21-tetramethoxy-13-methylhexacyclo[13.8.0.02,11.03,8.04,22.018,23]tricosa-1(15),2(11),3(8),4(22),5,9,12,16,18(23),20-decaene-7,19-dione |
| Solubility | Soluble in DMSO. |
| Appearance | White to off white powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Jiang Y, Leung AW, Wang X, et al. Effect of photodynamic therapy with hypocrellin B on apoptosis, adhesion, and migration of cancer cells. Int J Radiat Biol. 2014 Jul;90(7):575-9. PMID: 24661233.
Jiang Y, Leung AW, Wang X, et al. Inactivation of Staphylococcus aureus by photodynamic action of hypocrellin B. Photodiagnosis Photodyn Ther. 2013 Dec;10(4):600-6. PMID: 24284117.
Babu A, Jeyasubramanian K, Gunasekaran P, et al. Gelatin nanocarrier enables efficient delivery and phototoxicity of hypocrellin B against a mice tumour model. J Biomed Nanotechnol. 2012 Feb;8(1):43-56. PMID: 22515093.
Xu Y, Zhang Z, Zhang H. Raman spectroscopic study of DNA after photosensitive damage caused by hypocrellins A and B. Sci China C Life Sci. 1998 Aug;41(4):360-6. PMID: 18726251.