• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Irbesartan

Irbesartan

Product ID I6804
Cas No. 138402-11-6
Purity ≥98%
Product Unit SizeCostQuantityStock
50 mg $54.60 In stock
1 g $60.40 In stock
5 g $105.50 In stock
25 g $402.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Irbesartan is an angiotensin II type 1 (AT1) receptor inhibitor that also activates PPARγ receptors; it exhibits antihypertensive, cardioprotective, and anti-hyperlipidemic activities. In angiotensin-converting enzyme 2 (ACE2)-deficient mice, irbesartan decreases TGF-β1, atrial natriuretic factor, collagen, and phospho-ERK1/2 expression and increases PPARγ expression, reversing cardiac hypertrophy and myocardial fibrosis. In animal models of angiotensin II (ATII)-mediated abdominal aortic aneurysm, irbesartan prevents macrophage infiltration, pro-inflammatory cytokine release, smooth muscle attenuation, and medial elastolysis, and also limits aneurysm enlargement. In obese hypertensive rats, this compound decreases plasma levels of free fatty acids, triglycerides, and insulin; it also upregulates expression of hepatic PPARα. In high fat diet rats, irbesartan decreases body weight and adipose tissue weight and improves glucose metabolism and vascular function.

Product Info

Cas No.

138402-11-6

Purity

≥98%

Formula

C25H28N6O

Formula Wt.

428.53

Chemical Name

2-Butyl-3-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4,4]non-1-en-4-one

IUPAC Name

2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1, 3-diazaspiro[4.4]non-1-en-4-one

Synonym

Aprovel, Avapro

Melting Point

180-181°C

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

I6804 MSDS PDF

Info Sheet

I6804 Info Sheet PDF

References

Zhang ZZ, Shang QH, Jin HY, et al. Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice. J Transl Med. 2013 Sep 25;11(1):229. PMID: 24067190.

Iida Y, Xu B, Schultz GM, et al. Efficacy and mechanism of angiotensin II receptor blocker treatment in experimental abdominal aortic aneurysms. PLoS One. 2012;7(12):e49642. PMID: 23226500

Rong X, Li Y, Ebihara K, et al. Irbesartan treatment up-regulates hepatic expression of PPARalpha and its target genes in obese Koletsky (fa(k)/fa(k)) rats: a link to amelioration of hypertriglyceridaemia. Br J Pharmacol. 2010 Aug;160(7):1796-807. PMID: 20649581

de las Heras N, Martín-Fernández B, Miana M, et al. The protective effect of irbesartan in rats fed a high fat diet is associated with modification of leptin-adiponectin imbalance. J Hypertens Suppl. 2009 Aug;27(6):S37-41. PMID: 19633450.

Siragy H. Angiotensin II receptor blockers: review of the binding characteristics. Am J Cardiol. 1999 Nov 18;84(10A):3S-8S. PMID: 10588088.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S0269

    SAR245409

    Pyridopyrimidinone; PI3K and mTOR inhibitor.

    ≥96%
  • A145823

    ADU-S100 sodium salt

    Synthetic cyclic dinucleotide agonist of STING....

    ≥99%
  • C0375

    Ac-DEVD-pNA

    Caspase 3 substrate.

    ≥95%
  • N3213

    Nidulal

    Sesquiterpene found in Nidula.

    ≥95%
  • G124082

    GDC-0941

    pan-PI3K inhibitor.

    ≥98%
  • C2945

    Chlorophyllin Sodium-Copper Salt

    Semi-synthetic derivative of chlorophyll; food ...

    USP 28
  • D3209

    Diclofenac Sodium

    NSAID; COX-1/2 inhibitor, potential K+ channel ...

    ≥99%
  • A822686

    Aureothricin

    Aureothricin is a member of the dithiolopyrrolo...

    ≥98%
  • K4401

    KL-1 Peptide

    Peptide, c-Kit ligand fragment.

    ≥95%
  • L8009

    D-Luciferin 1-(4,5-dimethoxy-2-nitrophenyl) Ethyl Ester

    Cell-membrane permeable heterocyclic light-emit...

    ≥95%
  • R8179

    Rutaecarpine, synthetic

    Found in Evodia rutaecarpa; potential cAMP, 3β...

    ≥98%
  • I5210

    INCB018424

    JAK1/2 inhibitor.

    ≥98%
  • F1654

    Fenoldopam Mesylate

    Benzazepine derivative; D1 partial agonist, pot...

    ≥98%
  • K1679

    (+)-Ketanserin Tartrate

    5-HT2A and TRPV1 antagonist, potential α1-adre...

    ≥98%
  • M185770

    5-Methyltetrahydrofolic Acid

    Folic acid derivative

    ≥98%
  • C4558

    Clonidine Hydrochloride

    Imidazoline and α2-adrenergic agonist, Nav1.7 ...

    ≥98%
  • A5033

    4-Aminosalicylic Acid

    Dihydrofolate reductase inhibitor.

    ≥98%
  • K5606

    Kobe 2602

    Ras inhibitor.

    ≥98%
  • N3520

    Nifursol

    Nitrofuran, livestock antibiotic.

    ≥98%
  • M1774

    2-Mercaptoethanesulfonate Sodium

    Organosulfur, antioxidant.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only