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K252c

K252c

Product ID K0023
Cas No. 85753-43-1
Purity ≥98%
Product Unit SizeCostQuantityStock
0.5 mg $108.20 Please Inquire
1 mg $208.00 In stock
5 mg $873.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

K252c is an aglycone analog of staurosporine that acts as a protein kinase inhibitor, inhibiting PKC and potentially PKA. K252c inhibits proliferation of human cytomegalovirus (CMV) and induces apoptosis in cancer cells, indicating some antiviral and anticancer chemotherapeutic activities.

Product Info

Cas No.

85753-43-1

Purity

≥98%

Formula

C20H13N3O

Formula Wt.

311.34

Chemical Name

5-amino-2-[2-(dimethylamino)ethyl]benzo[de]isoquinoline-1,3-dione

IUPAC Name

5-amino-2-[2-(dimethylamino)ethyl]benzo[de]isoquinoline-1,3-dione

Synonym

Staurosporine aglycone

Solubility

Soluble in chloroform, acetonitrile, acetone, dioxane, tetrahydrofuran, pyridine; soluble in ethanol, methanol, 1-propanol, ethyl acetate and n-butanol; Insoluble in water, 2-propanol

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

K0023 MSDS PDF

Info Sheet

K0023 Info Sheet PDF

References

Liu R, Zhu T, Li D, et al. Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z(2)039-2. Arch Pharm Res. 2007 Mar;30(3):270-4. PMID: 17424930.

Zimmermann A, Wilts H, Lenhardt M, et al. Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase. Antiviral Res. 2000 Oct;48(1):49-60. PMID: 11080540.

Fabre S, Prudhomme M, Rapp M. Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds. Bioorg Med Chem. 1993 Sep;1(3):193-6. PMID: 8081852.

Custom Order

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