KN-93

Name: KN-93
SKU: K5200
Availability: InStock

Product ID K5200

Cas No. 1188890-41-6

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Add to Wishlist

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

KN-93 is an inhibitor of calmodulin-dependent kinase II (CaMKII); it may also inhibit L-type Ca2+ channels. KN-93 exhibits anticancer, anti-arrhythmic, cardiomodulatory, antinociceptive, and immunomodulatory activities. In vitro, KN-93 decreases VEGF expression. When combined with VEGF inhibitors, this compound decreases tumor growth in animal models of cancer. In other animal models, KN-93 prevents the development of arrhythmia and increases levels of Treg cells. KN-93 also increases withdrawal latency in animal models of thermal and mechanical pain.

Product Info

Cas No.	1188890-41-6
Purity	≥98%
Formula	C₂₆H₂₉ClN₂O₄S・H₃O₄P
Formula Wt.	599.03
Chemical Name	N-[2-({[(2E)-3-(4-Chlorophenyl)-2-propen-1-yl](methyl)amino}methyl)phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate (1:1)
IUPAC Name	N-[2-({[(2E)-3-(4-Chlorophenyl)-2-propen-1-yl](methyl)amino}methyl)phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate (1:1)
Synonym	2-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine
Solubility	Soluble in water
Appearance	White to off-white solid.

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	K5200 MSDS PDF
Info Sheet	K5200 Info Sheet PDF

References

Takeuchi M, Yamamoto T. Apoptosis induced by NAD depletion is inhibited by KN-93 in a CaMKII-independent manner. Exp Cell Res. 2015 Jul 1;335(1):62-7. PMID: 26024774.

Tzimas C, Terrovitis J, Lehnart SE, et al. Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition ameliorates arrhythmias elicited by junctin ablation under stress conditions. Heart Rhythm. 2015 Jul;12(7):1599-610. PMID: 25814413.

Daft PG, Yang Y, Napierala D, et al. The growth and aggressive behavior of human osteosarcoma is regulated by a CaMKII-controlled autocrine VEGF signaling mechanism. PLoS One. 2015 Apr 10;10(4):e0121568. PMID: 25860662.

Bian H, Yu LC. Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor KN93 induced antinociception in rats with mononeuropathy. Neurosci Lett. 2014 Nov 7;583:6-10. PMID: 25218714.

Koga T, Mizui M, Yoshida N, et al. KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3⁺ regulatory T cells in MRL/lpr mice. Autoimmunity. 2014 Nov;47(7):445-50. PMID: 24829059.