Description
Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities. In vitro, this compound inhibits cell growth and induces apoptosis and in vivo, it decreases tumor growth.
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Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities. In vitro, this compound inhibits cell growth and induces apoptosis and in vivo, it decreases tumor growth.
| Cas No. | 454453-49-7 |
|---|---|
| Purity | ≥98% |
| Formula | C14H9F4N5O4S |
| Formula Wt. | 419.31 |
| Chemical Name | 2-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioamide |
| IUPAC Name | 2-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioamide |
| Synonym | 2-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioamide |
| Solubility | DMSO: 15 mg/mL |
| Appearance | Light yellow solid |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Shima F, Yoshikawa Y, Ye M, et al. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8182-7. PMID: 23630290.
Shima F, Yoshikawa Y, Matsumoto S, et al. Discovery of small-molecule Ras inhibitors that display antitumor activity by interfering with Ras·GTP-effector interaction. Enzymes. 2013;34 Pt. B:1-23. PMID: 25034098.
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