Description
KT5283 is an inhibitor of PKG and is used to measure PKG activity and downstream effects of PKG/cGMP signaling.
KT5283 is an inhibitor of PKG and is used to measure PKG activity and downstream effects of PKG/cGMP signaling.
Cas No. | 126643-37-6 |
---|---|
Purity | ≥98% |
Formula | C28H23N3O5 |
Formula Wt. | 495.5 |
IUPAC Name | methyl (15S,16R,18R)-16-methoxy-4,15-dimethyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylate |
Solubility | DMSO, Ethyl Acetate |
Appearance | White Solid |
Store Temp | 4°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Salloum FN, Das A, Samidurai A, et al. Cinaciguat, a novel activator of soluble guanylate cyclase, protects against ischemia/reperfusion injury: role of hydrogen sulfide. Am J Physiol Heart Circ Physiol. 2012 Mar 15;302(6):H1347-54. PMID: 22268103.
Moreno H, Vega-Saenz de Miera E, Nadal MS, et al. Modulation of Kv3 potassium channels expressed in CHO cells by a nitric oxide-activated phosphatase. J Physiol. 2001 Feb 1;530(Pt 3):345-58. PMID: 11281123.
Abl, c-Kit, PDGFR inhibitor.
Sesquiterpene lactone found in Saussurea.
NSAID; COX-1/2 inhibitor.
Diterpene found in Salvia.
RyR agonist, SIRT, telomerase, P2Y, GPCR inhibi...
mTOR inhibitor.
Polyphenol found in olive oil, antioxidant.
Non-endogenous essential vitamin (B9), found in...
Dipeptide; aminopeptidase (N/CD13) inhibitor.
Pleuromutilin
STING antagonist
Diterpene found in coffee beans.
Pim kinase inhibitor.
Endogenous peptide hormone fragment, involved i...
ALK4/5/7 (activin-like) inhibitor, TGF-β inhib...
Labdane diterpene found in Andrographis; RLR (R...
Sulforaphane-cysteine conjugate.
ATP competitive CDK inhibitor.
Endogenous quaternary ammonium, required for fa...
Abl, PDGFR, EphR, Src, k-Kit, FYN, LCK, HCK inh...