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Laminin Peptide YIGSR

Laminin Peptide YIGSR

Product ID L0248
Cas No. 110590-64-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $88.00 Please Inquire
5 mg $283.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

This pentapeptide is equivalent to a sequence found on the B1 chain of laminin (929-933); it exhibits anticancer and anti-metastatic activities. Like other laminin peptide, this sequence can be used in combination with chemotherapeutics to deliver the drug to target tumor tissues. This peptide increases collagen type 1 synthesis in fibroblasts. In prostate cancer cells, this peptide decreases the mitochondrial membrane potential, inhibits ATP synthesis, and increases caspase 9 activity, inhibiting cell migration and growth.

Product Info

Cas No.

110590-64-2

Purity

≥98%

Formula

C26H42N8O8

Formula Wt.

594.66

IUPAC Name

Tyrosylisoleucylglycylseryl-N5-(diaminomethylene)ornithine

Solubility

Soluble in water(1 mg/mL).

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

L0248 MSDS PDF

Info Sheet

L0248 Info Sheet PDF

References

Yoon JH, Kim J, Lee H, et al. Laminin peptide YIGSR induces collagen synthesis in Hs27 human dermal fibroblasts. Biochem Biophys Res Commun. 2012 Nov 23;428(3):416-21. PMID: 23111328.

Dubey PK, Singodia D, Vyas SP. Polymeric nanospheres modified with YIGSR peptide for tumor targeting. Drug Deliv. 2010 Sep-Oct;17(7):541-51. PMID: 20560774.

Yu HN, Zhang LC, Yang JG, et al. Effect of laminin tyrosine-isoleucine-glycine-serine-arginine peptide on the growth of human prostate cancer (PC-3) cells in vitro. Eur J Pharmacol. 2009 Aug 15;616(1-3):251-5. PMID: 19577562.

Custom Order

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