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Lincomycin is a lincosamide antibiotic found in Streptomyces. Lincomycin exhibits antibacterial activity by binding the bacterial 50S ribosome subunit, inhibiting peptidyl transferase, and inducing dissociation of peptidyl-tRNA from the ribosome. Lincomycin also displays anti-parasitic/antimalarial activity against Plasmodium.
| Cas No. | 7179-49-9 |
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| Purity | ≥98% |
| Formula | C18H34N2O6S • HCl • H2O |
| Formula Wt. | 461.01 |
| Chemical Name | (2S-trans)-Methyl6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]-amino]-1-thio-D-erythro-α- D-galacto-octopyranoside hydrochloride monohydrate |
| IUPAC Name | (2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4, 5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4- propylpyrrolidine-2-carboxamide;hydrochloride |
| Synonym | Lincomycin hydrochloride monohydrate, Albiotic, Cillimycin, Lincomix |
| Melting Point | 156-158°C |
| Solubility | Soluble in water (50mg/mL). |
| Appearance | White or almost white crystal Powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Tenson T, Lovmar M, Ehrenberg M. The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome. J Mol Biol. 2003 Jul 25;330(5):1005-14. PMID: 12860123.
Menninger JR. Mechanism of inhibition of protein synthesis by macrolide and lincosamide antibiotics. J Basic Clin Physiol Pharmacol. 1995;6(3-4):229-50. PMID: 8852269.