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LY-2603618

LY-2603618

Product ID L9704
Cas No. 911222-45-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $68.30 In stock
5 mg $99.80 In stock
10 mg $183.80 In stock
25 mg $320.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

LY-2603618 is an inhibitor of checkpoint kinase (CHK) 1 that exhibits anticancer chemotherapeutic activity. In various animal models with tumor xenografts, this compound inhibits the S phase DNA damage checkpoint and increases DNA damage. In lung cancer cells, LY-2603618 induces G2/M phase cell cycle arrest and autophagy. LY-2603618 also enhances activity of other co-administered chemotherapeutics such as gemcitabine.

Product Info

Cas No.

911222-45-2

Purity

≥98%

Formula

C18H22BrN5O3

Formula Wt.

436.31

Chemical Name

1-[5-bromo-4-methyl-2-[[(2S)-morpholin-2-yl]methoxy]phenyl]-3-(5-methylpyrazin-2-yl)urea

IUPAC Name

1-{5-Bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl}-3-(5-methyl-2-pyrazinyl)urea

Synonym

Rabusertib

Solubility

13mg/mL in DMSO, insoluble in water and ethanol

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

L9704 MSDS PDF

Info Sheet

L9704 Info Sheet PDF

References

Barnard D, Diaz HB, Burke T, et al. LY2603618, a selective CHK1 inhibitor, enhances the anti-tumor effect of gemcitabine in xenograft tumor models. Invest New Drugs. 2015 Nov 27. [Epub ahead of print]. PMID: 26612134.

Wang FZ, Fei HR, Cui YJ, et al. The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Apoptosis. 2014 Sep;19(9):1389-98. PMID: 24928205.

King C, Diaz H, Barnard D, et al. Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor. Invest New Drugs. 2014 Apr;32(2):213-26. PMID: 24114124.

Custom Order

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