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LY-404187 is a selective positive allosteric modulator of AMPA receptors. It causes enhanced cognitive function in a variety of ways, including augmenting synaptic activity due to direct potentiation of AMPA receptor function, increasing neurotrophin expression, and modulating glutamatergic transmission.
| Cas No. | 211311-95-4 |
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| Purity | ≥98% |
| Formula | C19H22N2O2S |
| Formula Wt. | 342.46 |
| IUPAC Name | N-[2-(4'-Cyano-4-biphenylyl)propyl]-2-propanesulfonamide |
| Synonym | LY404187 |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Quirk J., Nisenbaum E. LY404187: a novel positive allosteric modulator of AMPA receptors. CNS Drug Rev. 8(3):255-82 (2002). PMID: 12353058.
O’Neill M., Bleakman D., et al. AMPA receptor potentiators for the treatment of CNS disorders. Curr Drug Targets CNS Neurol Disord. 3(3):181-94 (2004). PMID:15180479.