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Laminin Peptide CDPGYIGSR

Laminin Peptide CDPGYIGSR

Product ID L0251
Cas No. 110590-60-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $204.90 In stock
5 mg $787.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

This nonapeptide is equivalent to a sequence found on the B1 chain of laminin (925-933); it exhibits vasoconstrictive, anti-metastatic, and anti-angiogenic activities. This peptide increases vascular tone, producing vasoconstriction and inducing Ca2+ influx in vascular smooth muscle cells; it also activates nonselective cation channels. In vitro, this peptide inhibits angiogenesis and cell migration. In vivo, this peptide inhibits growth of sarcoma 180 tumors and Lewis lung carcinoma tumors. Like other laminin peptides, this sequence can be used in combination with chemotherapeutics to deliver the drug to target tumor tissues.

Product Info

Cas No.

110590-60-8

Purity

≥98%

Formula

C40H62N12O14S

Formula Wt.

967.06

IUPAC Name

L-Cysteinyl-L-α-aspartyl-L-prolylglycyl-L-tyrosyl-L-isoleucylglycyl-L-seryl-N5-(diaminomethylene)-L-ornithine

Synonym

Laminin (925-933)

Solubility

Soluble in water, DMSO (45 mg/mL).

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

L0251 MSDS PDF

Info Sheet

L0251 Info Sheet PDF

References

Wenzel D, Koch M, Matthey M, et al. Identification of a novel vasoconstrictor peptide specific for the systemic circulation. Hypertension. 2012 Jun;59(6):1256-62. PMID: 22547445.

Sakamoto N, Iwahana M, Tanaka NG, et al. Inhibition of angiogenesis and tumor growth by a synthetic laminin peptide, CDPGYIGSR-NH2. Cancer Res. 1991 Feb 1;51(3):903-6. PMID: 1703042.

Custom Order

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