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Milrinone

Milrinone

Product ID M3344
Cas No. 78415-72-2
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $134.30 In stock
50 mg $554.10 In stock
100 mg $954.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Milrinone is an inhibitor of phosphodiesterase 3 (PDE3) that exhibits vasodilatory activity; it is clinically used to treat heart failure. Milrinone increases cAMP, PKA activation, and Ca2+ influx, strengthening contractility. Milrinone also exhibits anticoagulant activity, inhibiting platelet aggregation by preventing Ca2+ release from the dense tubular system.

Product Info

Cas No.

78415-72-2

Purity

≥98%

Formula

C12H9N3O

Formula Wt.

211.22

Chemical Name

5,8-Dihydro-5-methoxy-8-oxo-1,3-dioxolo[4,5-g]- quinoline-7-carboxylic acid

IUPAC Name

6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile

Synonym

Corotrope, Milrila

Melting Point

264°C

Solubility

Soluble in DMSO (>10mg/mL).

Appearance

A Off-White to Tan Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M3344 MSDS PDF

Info Sheet

M3344 Info Sheet PDF

References

Hiramatsu N, Kageyama K. Anti-thrombotic effect of milrinone is caused by inhibition of calcium release from the dense tubular system in human platelets. Acta Anaesthesiol Scand. 2003 Jan;47(1):53-7. PMID: 12492797.

Yano M, Kohno M, Ohkusa T, et al. Effect of milrinone on left ventricular relaxation and Ca(2+) uptake function of cardiac sarcoplasmic reticulum. Am J Physiol Heart Circ Physiol. 2000 Oct;279(4):H1898-905. PMID: 11009478.

Custom Order

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