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Nadifloxacin is a fluoroquinolone antibiotic that exhibits antibacterial efficacy against both gram positive and gram negative bacteria; it inhibits DNA gyrase and is clinically used to treat acne vulgaris. Nadifloxacin inhibits Proponibacterium-stimulated PBMC production of IL-12, IFN-γ, and other cytokines. Nadifloxacin also decreases production of oxidative radicals by neutrophils.
| Cas No. | 124858-35-1 |
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| Purity | ≥98% |
| Formula | C19H21FN2O4 |
| Formula Wt. | 360.38 |
| Chemical Name | (+-)-9-Fluoro-6,7-dihydro-8-(4-hydroxypiperidino)-5-methyl- 1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid |
| IUPAC Name | 7-fluoro-8-(4-hydroxypiperidin-1-yl)-12-methyl-4-oxo-1-azatricyclo[7.3.1.05,13]trideca-2,5,7,9(13)-tetraene-3-carboxylic acid |
| Synonym | Jinofloxacin, Acuatim |
| Melting Point | 245-247°C |
| Solubility | Soluble in DMSO. |
| Appearance | Pale yellow or yellow crystalline powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Takenaka Y, Hayashi N, Takeda M, et al. Glycolic acid chemical peeling improves inflammatory acne eruptions through its inhibitory and bactericidal effects on Propionibacterium acnes. J Dermatol. 2012 Apr;39(4):350-4. PMID: 21950544.
Kuwahara K, Kitazawa T, Kitagaki H, et al. Nadifloxacin, an antiacne quinolone antimicrobial, inhibits the production of proinflammatory cytokines by human peripheral blood mononuclear cells and normal human keratinocytes. J Dermatol Sci. 2005 Apr;38(1):47-55. PMID: 15795123.
Akamatsu H, Sasaki H, Kurokawa I, et al. Effect of nadifloxacin on neutrophil functions. J Int Med Res. 1995 Jan-Feb;23(1):19-26. PMID: 7774755.