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Neosolaniol is a type A trichothecene mycotoxin initially produced by species of Fusarium. Neosolaniol is typically found in grains used for livestock feed as well as human consumption, such as cereal and bread. Neosolaniol is mainly cytotoxic to dividing cells. In vitro, neosolaniol decreases erythrocyte counts and increases large platelet counts.
| Cas No. | 36519-25-2 |
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| Purity | ≥98% |
| Formula | C19H26O8 |
| Formula Wt. | 382.40 |
| Chemical Name | [(1S,2R,4S,7R,9R,10R,11S,12S)-11-acetyloxy-4,10-dihydroxy-1,5-dimethylspiro[8-oxatricyclo[7.2.1.02,7]dodec-5-ene-12,2'-oxirane]-2-yl]methyl acetate |
| IUPAC Name | [(1S,2R,4S,7R,9R,10R,11S,12S)-11-acetyloxy-4,10-dihydroxy-1,5-dimethylspiro[8-oxatricyclo[7.2.1.02,7]dodec-5-ene-12,2'-oxirane]-2-yl]methyl acetate |
| Synonym | Solaniol |
| Melting Point | 176-178°C |
| Solubility | Soluble in DMSO (10 mg/mL), methanol (10 mg/mL). |
| Appearance | Slight Yellow Powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Monbaliu S, Van Poucke C, Detavernier C, et al. Occurrence of mycotoxins in feed as analyzed by a multi-mycotoxin LC-MS/MS method. J Agric Food Chem. 2010 Jan 13;58(1):66-71. PMID: 19994896.
Gottschalk C, Barthel J, Engelhardt G, et al. Occurrence of type A trichothecenes in conventionally and organically produced oats and oat products. Mol Nutr Food Res. 2007 Dec;51(12):1547-53. PMID: 18030660.
Altomare C, Ritieni A, Perrone G, et al. Production of neosolaniol by Fusarium tumidum. Mycopathologia. 1995 Jun;130(3):179-84. PMID: 7566071.
Janse van Rensburg DF, Thiel PG, Jaskiewicz K. Short-term effects of two fusarium toxins, diacetoxyscirpenol and neosolaniol monoacetate, in male Wistar rats. Food Chem Toxicol. 1987 Oct;25(10):767-71. PMID: 3679023.