LKT Labs

Biochemicals for Life Science Research

Neuromedin

Neuromedin

Product ID N1979
Cas No. 102577-25-3
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $65.40 In stock
2 mg $111.60 In stock
5 mg $196.20 In stock
Bulk Quote

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Description

Neuromedin N is an endogenous proneurotensin peptide involved in energy homeostasis regulation; it modulates hypothalamic thermoregulatory signaling in animal models and induces contraction in ileal smooth muscle cells. Neuromedin N also inhibits reward/reinforcement signaling by inhibiting the intracranial self-stimulation (ICSS) in animal models of reward and reinforcement. Src activates proneurotensin/neuromedin N promoter activity in a Raf-dependent manner. Additionally, neuromedin N is inactivated by dipeptidyl peptidases and aminopeptidases.

Product Info

Cas No.

102577-25-3
Purity

≥95%
Formula

C38H63N7O8
Formula Wt.

745.97
IUPAC Name

(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid
Synonym

Neuromedin N
Solubility

Soluble in water (0.5 mg/mL).

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

N1979 MSDS PDF
Info Sheet

N1979 Info Sheet PDF

References

Basir YJ, Knoop FC, Dulka J, et al. Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris. Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. PMID: 11087945.

Banker NA, Hellmich MR, Kim HJ, et al. Src-mediated activation of the human neurotensin/neuromedin N promoter. Surgery. 1997 Aug;122(2):180-6. PMID: 9288121.

Fernández R, Alba F, Ferrer JM. Peptidase inhibitors potentiate the effects of neurotensin and neuromedin N on self-stimulation of the medial prefrontal cortex. Neuroreport. 1996 Feb 29;7(3):798-800. PMID: 8733748.

Barelli H, Woskowska Z, Cipris S, et al. Pharmacological role and degradation processes of neuromedin N in the gastrointestinal tract: an in vitro and in vivo study. J Pharmacol Exp Ther. 1995 Dec;275(3):1300-7. PMID: 8531096.

Malendowicz LK, Nussdorfer GG, Markowska A, et al. Investigations on the acute effects of neuropeptides on the pituitary-adrenocortical function in normal and cold-stressed rats. II. Neurotensin and neuromedin N. Exp Toxicol Pathol. 1995 Jan;47(1):41-5. PMID: 7719120.

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