Neuromedin

Name: Neuromedin
SKU: N1979
Availability: InStock

Product ID N1979

Cas No. 102577-25-3

Purity ≥95%

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Description

Neuromedin N is an endogenous proneurotensin peptide involved in energy homeostasis regulation; it modulates hypothalamic thermoregulatory signaling in animal models and induces contraction in ileal smooth muscle cells. Neuromedin N also inhibits reward/reinforcement signaling by inhibiting the intracranial self-stimulation (ICSS) in animal models of reward and reinforcement. Src activates proneurotensin/neuromedin N promoter activity in a Raf-dependent manner. Additionally, neuromedin N is inactivated by dipeptidyl peptidases and aminopeptidases.

Product Info

Cas No.	102577-25-3
Purity	≥95%
Formula	C₃₈H₆₃N₇O₈
Formula Wt.	745.97
IUPAC Name	(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid
Synonym	Neuromedin N
Solubility	Soluble in water (0.5 mg/mL).

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	N1979 MSDS PDF
Info Sheet	N1979 Info Sheet PDF

References

Basir YJ, Knoop FC, Dulka J, et al. Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris. Biochim Biophys Acta. 2000 Nov 30;1543(1):95-105. PMID: 11087945.

Banker NA, Hellmich MR, Kim HJ, et al. Src-mediated activation of the human neurotensin/neuromedin N promoter. Surgery. 1997 Aug;122(2):180-6. PMID: 9288121.

Fernández R, Alba F, Ferrer JM. Peptidase inhibitors potentiate the effects of neurotensin and neuromedin N on self-stimulation of the medial prefrontal cortex. Neuroreport. 1996 Feb 29;7(3):798-800. PMID: 8733748.

Barelli H, Woskowska Z, Cipris S, et al. Pharmacological role and degradation processes of neuromedin N in the gastrointestinal tract: an in vitro and in vivo study. J Pharmacol Exp Ther. 1995 Dec;275(3):1300-7. PMID: 8531096.

Malendowicz LK, Nussdorfer GG, Markowska A, et al. Investigations on the acute effects of neuropeptides on the pituitary-adrenocortical function in normal and cold-stressed rats. II. Neurotensin and neuromedin N. Exp Toxicol Pathol. 1995 Jan;47(1):41-5. PMID: 7719120.

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Neuromedin

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