LKT Labs

Biochemicals for Life Science Research

Nicergoline

Nicergoline

Product ID N3210
Cas No. 27848-84-6
Purity ≥98%
Product Unit SizeCostQuantityStock
250 mg $97.00 In stock
500 mg $175.00 In stock
1 g $292.00 In stock
Bulk Quote

Quicklinks

Description

Nicergoline is an ergot derivative from the fungi genus Claviceps. Nicergoline exhibits anti-atherosclerotic and antithrombotic activity, used to treat vascular disorders including thrombosis, atherosclerosis, Reynaud’s disease, and retinopathy. This compound acts as an α1-adrenergic receptor inhibitor and also inhibits platelet aggregation. Additionally, nicergoline shows neuroprotective benefit, increasing glutamate uptake and levels of BDNF and substance P in the brain. Nicergoline also decreases levels of pro-inflammatory cytokines TNF-α, IL-6, and IL-1β.

Product Info

Cas No.

27848-84-6
Purity

≥98%
Formula

C24H26BrN3O3
Formula Wt.

484.39
Chemical Name

5-Bromonicotinic acid 10-methoxy-1,6-dimethylergoline-8-methyl ester
IUPAC Name

[(6aR,9R,10aS)-10a-methoxy-4,7-dimethyl-6a,8,9,10-tetrahydro-6H-indolo[4,3-fg]quinoline-9-yl]methyl 5-bromopyridine-3-carboxylate
Synonym

Nicotergoline; Nimergoline; Nimergoline base; Nicergolinum
Solubility

soluble in DMSO; alcohol, chloroform, and acetone

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

N3210 MSDS PDF
Info Sheet

N3210 Info Sheet PDF

References

Nishiyama Y, Abe A, Ueda M, et al. Nicergoline increases serum substance P levels in patients with an ischaemic stroke. Cerebrovasc Dis. 2010 Jan;29(2):194-8. PMID: 20029189.

Schardl CL, Panaccione DG, Tudzynski P. Ergot alkaloids--biology and molecular biology. Alkaloids Chem Biol. 2006;63:45-86. PMID: 17133714.

Mizuno T, Kuno R, Nitta A, et al. Protective effects of nicergoline against neuronal cell death induced by activated microglia and astrocytes. Brain Res. 2005 Dec 20;1066(1-2):78-85. PMID: 16325157.

Nishida A, Iwata H, Kudo Y, et al. Nicergoline enhances glutamate uptake via glutamate transporters in rat cortical synaptosomes. Biol Pharm Bull. 2004 Jun;27(6):817-20. PMID: 15187425.

Fioravanti M, Flicker L. Efficacy of nicergoline in dementia and other age associated forms of cognitive impairment. Cochrane Database Syst Rev. 2001;(4):CD003159. PMID: 11687175.

Alvarez-Guerra M, Bertholom N, Garay RP. Selective blockade by nicergoline of vascular responses elicited by stimulation of alpha 1A-adrenoceptor subtype in the rat. Fundam Clin Pharmacol. 1999;13(1):50-8. PMID: 10027088.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • F4679

    Flubendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥98%
  • C7098

    Crystalline peptide

    Dipeptide.

    ≥95%
  • L5862

    Lopinavir

    HIV protease inhibitor, SERCA inhibitor.

    ≥98%
  • A4924

    AMG-208

    c-MET and Ron inhibitor.

    ≥98%
  • G733409

    GSK-2982772

    RIP1 inhibitor.

    ≥98%
  • G346851

    Givinostat Hydrochloride

    Non-selective HDAC inhibitor.

    ≥98%
  • E9417

    Exendin-4

    Peptide, GLP-1 analog found in Heloderma; GLP-1...

    ≥95%
  • G0104

    Gabexate Mesylate

    Proteasome inhibitor.

    ≥99%
  • G3358

    Ginkgolide ABC

    Mixture of Ginkgolides A, B and C, found in Gin...

    ≥98%
  • I761004

    Itaconic Acid

    Polymer precursor

    ≥99%
  • L5769

    Lorglumide Sodium

    CCK antagonist.

    ≥98%
  • S6800

    SR1001

    RORα/γ inverse agonist.

    ≥99%
  • V574451

    Volitinib

    c-Met inhibitor.

    ≥98%
  • G3554

    Ginsenoside Rb3

    Triterpene saponin found in species of Panax.

    ≥98%
  • C0374

    β-Casomorphin, human

    Peptide, casein fragment.

    ≥95%
  • F3354

    Finasteride

    Steroid 5-α-reductase inhibitor.

    ≥98%
  • E7378

    Estrone

    Endogenous steroid hormone, estriol precursor; ...

    ≥97%
  • K7600

    KT5720

    PKA and PDK1 inhibitor, HCN channel blocker, po...

    ≥98%
  • A851322

    Avibactam Sodium

    Diazabicyclooctane β-lactamase inhibitor.

    ≥98%
  • L186858

    Levomefolic acid

    Folic acid derivative

    ≥98%