• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Nicergoline

Nicergoline

Product ID N3210
Cas No. 27848-84-6
Purity ≥98%
Product Unit SizeCostQuantityStock
250 mg $97.20 In stock
500 mg $174.90 In stock
1 g $291.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Nicergoline is an ergot derivative from the fungi genus Claviceps. Nicergoline exhibits anti-atherosclerotic and antithrombotic activity, used to treat vascular disorders including thrombosis, atherosclerosis, Reynaud’s disease, and retinopathy. This compound acts as an α1-adrenergic receptor inhibitor and also inhibits platelet aggregation. Additionally, nicergoline shows neuroprotective benefit, increasing glutamate uptake and levels of BDNF and substance P in the brain. Nicergoline also decreases levels of pro-inflammatory cytokines TNF-α, IL-6, and IL-1β.

Product Info

Cas No.

27848-84-6

Purity

≥98%

Formula

C24H26BrN3O3

Formula Wt.

484.39

Chemical Name

5-Bromonicotinic acid 10-methoxy-1,6-dimethylergoline-8-methyl ester

IUPAC Name

[(6aR,9R,10aS)-10a-methoxy-4,7-dimethyl-6a,8,9,10-tetrahydro-6H-indolo[4,3-fg]quinoline-9-yl]methyl 5-bromopyridine-3-carboxylate

Synonym

Nicotergoline; Nimergoline; Nimergoline base; Nicergolinum

Solubility

soluble in DMSO; alcohol, chloroform, and acetone

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

N3210 MSDS PDF

Info Sheet

N3210 Info Sheet PDF

References

Nishiyama Y, Abe A, Ueda M, et al. Nicergoline increases serum substance P levels in patients with an ischaemic stroke. Cerebrovasc Dis. 2010 Jan;29(2):194-8. PMID: 20029189.

Schardl CL, Panaccione DG, Tudzynski P. Ergot alkaloids--biology and molecular biology. Alkaloids Chem Biol. 2006;63:45-86. PMID: 17133714.

Mizuno T, Kuno R, Nitta A, et al. Protective effects of nicergoline against neuronal cell death induced by activated microglia and astrocytes. Brain Res. 2005 Dec 20;1066(1-2):78-85. PMID: 16325157.

Nishida A, Iwata H, Kudo Y, et al. Nicergoline enhances glutamate uptake via glutamate transporters in rat cortical synaptosomes. Biol Pharm Bull. 2004 Jun;27(6):817-20. PMID: 15187425.

Fioravanti M, Flicker L. Efficacy of nicergoline in dementia and other age associated forms of cognitive impairment. Cochrane Database Syst Rev. 2001;(4):CD003159. PMID: 11687175.

Alvarez-Guerra M, Bertholom N, Garay RP. Selective blockade by nicergoline of vascular responses elicited by stimulation of alpha 1A-adrenoceptor subtype in the rat. Fundam Clin Pharmacol. 1999;13(1):50-8. PMID: 10027088.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P2100

    PF-06447475

    LRRK2 inhibitor.

    ≥98%
  • H9620

    7-Hydroxyaristolochic Acid A

    Derivative of aristolochic acid found in Asarum...

    ≥95%
  • A0920

    N-Acetyl-S-(N′-phenethylthiocarbamoyl)-L-cysteine

    N-acetyl cysteine conjugate of phenethylisothio...

    ≥95%
  • E2003

    Efavirenz

    Non-nucleoside RT inhibitor.

    ≥99%
  • V024761

    Vatalanib

    Inhibitor of VEGFR1/2/3.

    ≥98%
  • A5284

    [Val5]-Angiotensin II, human

    Peptide, derivative of AT II, involved in vasoc...

    ≥95%
  • A4534

    Aliskiren Hemifumarate

    Renin inhibitor.

    ≥98%
  • C0261

    Captopril

    ACE inhibitor.

    ≥98%
  • M7200

    MS436

    BRD4 inhibitor.

    ≥99%
  • G7232

    GS-9973

    Syk inhibitor.

    ≥98%
  • S6000

    Sparfloxacin

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • I7341

    Isoniazid

    Nicotinic acid derivative; InhA inhibitor.

    ≥98%
  • G7345

    GSK-2606414

    PERK inhibitor.

    ≥99%
  • C5662

    Copper Bis-3,5-diisopropylsalicylate

    Antioxidant.

    ≥97%
  • P698574

    Prolylrapamycin

    Rapamycin analog

  • A0501

    Abamectin

    Macrocyclic lactone avermectin; GABA antagonist...

    ≥70%
  • P4403

    Plasminogen Activator Inhibitor 1

    Endogenous peptide, produced by activation of P...

    ≥95%
  • H965143

    Hydrolyzed Fumonisin B2

    Mycotoxin produced by Fusarium fungi that infec...

    ≥97% by ELSD
  • T5672

    Tosufloxacin Tosylate

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • C0377

    Catharanthine Sulfate

    Alkaloid found in Catharanthus, precursor in sy...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only