• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Nivalenol

Nivalenol

Product ID N3584
Cas No. 23282-20-4
Purity ≥98%
Product Unit SizeCostQuantityStock
0.5 mg $90.20 Please Inquire
1 mg $170.40 In stock
5 mg $613.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Nivalenol is a Fusarium type B trichothecene mycotoxin. Nivalenol is cytotoxic to leukocytes, inhibiting cell proliferation, increasing IL-8 secretion, and decreasing MCP-1 secretion in an NF-κB-dependent manner. In macrophages and Jurkat T cells, nivalenol increases cytochrome c release and degradation of Bcl-2, stimulating caspase 3-mediated apoptosis. Additionally, nivalenol induces the breakdown of polyribosomes and inhibits polypeptide chain initiation in eukaryotes.

Product Info

Cas No.

23282-20-4

Purity

≥98%

Formula

C15H20O7

Formula Wt.

312.32

Chemical Name

(1S,2R,3S,7R,9R,10R,11S,12S)-3,10,11-trihydroxy-2-(hydroxymethyl)-1,5-dimethylspiro[8-oxatricyclo[7.2.1.02,7]dodec-5-ene-12,2'-oxirane]-4-one

IUPAC Name

(1S,2R,3S,7R,9R,10R,11S,12S)-3,10,11-trihydroxy-2-(hydroxymethyl)-1,5-dimethylspiro[8-oxatricyclo[7.2.1.02,7]dodec-5-ene-12,2'-oxirane]-4-one

Melting Point

127-130°C

Solubility

DMSO, Methanol, dichloromethane. Slightly soluble in water.

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

N3584 MSDS PDF

Info Sheet

N3584 Info Sheet PDF

References

Alassane-Kpembi I, Kolf-Clauw M, Gauthier T, et al. New insights into mycotoxin mixtures: the toxicity of low doses of Type B trichothecenes on intestinal epithelial cells is synergistic. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):191-8. PMID: 23735874.

Wu W, Flannery BM, Sugita-Konishi Y, et al. Comparison of murine anorectic responses to the 8-ketotrichothecenes 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, fusarenon X and nivalenol. Food Chem Toxicol. 2012 Jun;50(6):2056-61. PMID: 22465835.

Nagashima H, Kushiro M, Nakagawa H. Nuclear factor-κB inhibitors alleviate nivalenol-induced cytotoxicity in HL60 cells. Environ Toxicol Pharmacol. 2011 Jan;31(1):258-61. PMID: 21787693.

Marzocco S, Russo R, Bianco G, et al. Pro-apoptotic effects of nivalenol and deoxynivalenol trichothecenes in J774A.1 murine macrophages. Toxicol Lett. 2009 Aug 25;189(1):21-6. PMID: 19410639.

Nasri T, Bosch RR, Voorde St, et al. Differential induction of apoptosis by type A and B trichothecenes in Jurkat T-lymphocytes. Toxicol In Vitro. 2006 Sep;20(6):832-40. PMID: 16472964.

Cundliffe E, Cannon M, Davies J. Mechanism of inhibition of eukaryotic protein synthesis by trichothecene fungal toxins. Proc Natl Acad Sci U S A. 1974 Jan;71(1):30-4. PMID: 4521056.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • V1745

    Veliparib

    PARP inhibitor.

    ≥99%
  • X1753

    Xenopsin

    Peptide hormone, neurotensin analog found in am...

    ≥95%
  • N5778

    Notoginsenoside R1

    Triterpene saponin found in species of Panax.

    ≥98%
  • T0092

    1-Hydroxybaccatin I

    Diterpene found in Taxus; potential microtubule...

    ≥98%
  • T1679

    Tetracycline Hydrochloride

    Polyketide; protein translation inhibitor, mamm...

    ≥95%
  • C0044

    CAL101

    p110δ PI3K inhibitor.

    ≥99%
  • N1979

    Neuromedin

    Endogenous proneurotensin peptide, involved in ...

    ≥95%
  • P8169

    Purpurin

    Anthraquinone pigment found in madder root; O-a...

    ≥90%
  • E622698

    Eprosartan Mesylate

    Nonpeptide angiotensin II receptor antagonist

    ≥99%
  • P698579

    Propantheline Bromide

    Antimuscarinic

    ≥98%
  • D6958

    Droloxifene Citrate

    Tamoxifen analog; SERM.

    ≥98%
  • A2244

    Aflatoxicol

    Mycotoxin, metabolite of aflatoxin B1 produced ...

    ≥98%
  • S8047

    R,S-Sulforaphane, Research Grade

    Synthetic ITC.

    ≥97%
  • C0369

    Cardiogenol C Hydrochloride

    Induces cardiomyogenic effects in pluripotent c...

    ≥98%
  • P3076

    PHT-427

    PDK1 and Akt inhibitor.

    ≥98%
  • C0147

    Calcium Folinate Pentahydrate

    Folate source co-administered with methotrexate...

    ≥95%
  • O9302

    Oxacillin Sodium Monohydrate

    β-lactam; penicillin binding protein inhibitor...

    ≥98%
  • E4444

    Ellagic Acid

    Phenol found in various fruits; HDAC modulator....

    ≥98%
  • T0394

    (+)-Taxifolin

    Catechol-type flavonoid; fatty acid synthesis i...

    ≥98%
  • T0096

    Cephalomannine

    Diterpene found in Taxus; potential microtubule...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only