LKT Labs

Biochemicals for Life Science Research

Norfloxacin Nicotinate

Norfloxacin Nicotinate

Product ID N5769
Cas No. 118803-81-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $51.00 In stock
10 g $125.00 In stock
50 g $385.00 In stock
Bulk Quote

Quicklinks

Description

Norfloxacin is a first generation fluoroquinolone antibiotic that exhibits antibacterial, anti-inflammatory, and anticancer activities. Norfloxacin inhibits DNA gyrase and topoisomerase IV; it is clinically used to treat urinary tract infections and prostatitis. In neutrophils from cirrhotic subjects, norfloxacin increases expression of IL-10 and heme oxygenase 1 (HO-1) and decreases expression of pro-inflammatory cytokines. Additionally, when complexed with gold(III), norfloxacin binds DNA and inhibits cellular proliferation in several cancer cell lines.

Product Info

Cas No.

118803-81-9
Purity

≥98%
Formula

C16H18FN3O3 • C6H5NO2
Formula Wt.

442.44
IUPAC Name

1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;pyridine-3-carboxylic acid
Melting Point

220-227°C
Solubility

Soluble in water.

Appearance

White/Slight Yellow Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

N5769 MSDS PDF
Info Sheet

N5769 Info Sheet PDF

References

Gouvea LR, Garcia LS, Lachter DR, et al. Atypical fluoroquinolone gold(III) chelates as potential anticancer agents: relevance of DNA and protein interactions for their mechanism of action. Eur J Med Chem. 2012 Sep;55:67-73. PMID: 22835721.

Gómez-Hurtado I, Zapater P, Bellot P, et al. Interleukin-10-mediated heme oxygenase 1-induced underlying mechanism in inflammatory down-regulation by norfloxacin in cirrhosis. Hepatology. 2011 Mar;53(3):935-44. PMID: 21374664.

Padeĭskaia EN. Norfloxacin: more than 20 years of clinical use, the results and place among fluoroquinolones in modern chemotherapy for infections. Antibiot Khimioter. 2003;48(9):28-36. PMID: 15002177.

Drlica K, Zhao X. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. PMID: 9293187.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G5320

    GNF-2

    Abl inhibitor.

    ≥98%
  • C0169

    Carbenoxolone Disodium

    Synthetic derivative of glycyrrhizin; connexin ...

    ≥97%
  • D5868

    Doramapimod

    JNK, ALK, p38 MAPK inhibitor.

    ≥99%
  • T3097

    Thymosin α-1 Acetate

    Endogenous peptide, involved in hormone regulat...

    ≥95%
  • K040009

    KB-0742 dihydrochloride

    CDK9 inhibitor.

    ≥99%
  • C1633

    Cefotaxime Sodium

    β-lactam cephalosporin; penicillin binding pro...

    ≥96%
  • D564090

    7-epi-Docetaxel

    Docetaxel impurity

    ≥95%
  • D3212

    2′,3′-Dideoxycytidine

    Pyrimidine nucleoside (cytidine) analog; DNA ch...

    ≥98%
  • L8008

    D-Luciferin, firefly, Free Acid

    Heterocyclic light-emitting compound, natural l...

    ≥98%
  • M3598

    Mizoribine Hydrobromide

    IMPDH inhibitor.

    ≥98%
  • I4934

    Imipenem Monohydrate

    Carbapenem β-lactam; penicillin binding protei...

    ≥98%
  • P1760

    Peptide T

    Peptide fragment of HIV-1 gp120.

    ≥98%
  • A6269

    Apremilast

    PDE4 inhibitor.

    ≥98%
  • S771339

    STING Agonist-12

    STING activator

    ≥99%
  • A0964

    Adrenocorticotropic Hormone (1-13), human

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • M0125

    Magnolol

    Lignan found in Magnolia; GABA-A potentiator.

    ≥98%
  • D1694

    Dexamethasone Acetate Monohydrate

    Steroid; glucocorticoid agonist.

    ≥98%
  • D023721

    Dasatinib

    Multikinase inhibitor.

    ≥99%
  • A971336

    Azilsartan Medoxomil

    Prodrug

    ≥98%
  • K0552

    Kb NB 77-78

    CID-797718 analog; potential PKD1 binding agent...

    ≥98%