LKT Labs

Biochemicals for Life Science Research

Norfloxacin Nicotinate

Norfloxacin Nicotinate

Product ID N5769
Cas No. 118803-81-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $51.00 In stock
10 g $125.00 In stock
50 g $385.00 In stock
Bulk Quote

Quicklinks

Description

Norfloxacin is a first generation fluoroquinolone antibiotic that exhibits antibacterial, anti-inflammatory, and anticancer activities. Norfloxacin inhibits DNA gyrase and topoisomerase IV; it is clinically used to treat urinary tract infections and prostatitis. In neutrophils from cirrhotic subjects, norfloxacin increases expression of IL-10 and heme oxygenase 1 (HO-1) and decreases expression of pro-inflammatory cytokines. Additionally, when complexed with gold(III), norfloxacin binds DNA and inhibits cellular proliferation in several cancer cell lines.

Product Info

Cas No.

118803-81-9
Purity

≥98%
Formula

C16H18FN3O3 • C6H5NO2
Formula Wt.

442.44
IUPAC Name

1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;pyridine-3-carboxylic acid
Melting Point

220-227°C
Solubility

Soluble in water.

Appearance

White/Slight Yellow Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

N5769 MSDS PDF
Info Sheet

N5769 Info Sheet PDF

References

Gouvea LR, Garcia LS, Lachter DR, et al. Atypical fluoroquinolone gold(III) chelates as potential anticancer agents: relevance of DNA and protein interactions for their mechanism of action. Eur J Med Chem. 2012 Sep;55:67-73. PMID: 22835721.

Gómez-Hurtado I, Zapater P, Bellot P, et al. Interleukin-10-mediated heme oxygenase 1-induced underlying mechanism in inflammatory down-regulation by norfloxacin in cirrhosis. Hepatology. 2011 Mar;53(3):935-44. PMID: 21374664.

Padeĭskaia EN. Norfloxacin: more than 20 years of clinical use, the results and place among fluoroquinolones in modern chemotherapy for infections. Antibiot Khimioter. 2003;48(9):28-36. PMID: 15002177.

Drlica K, Zhao X. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. PMID: 9293187.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D178589

    1-Deoxynojirimycin

    Anti-diabetic alkaloid

    ≥98%
  • S0500

    SB-203580

    p38 MAPK inhibitor.

    ≥98%
  • T0115

    Taxol Side Chain Acid

    Side chain commonly attached to taxanes.

    ≥98%
  • O9334

    Oxibendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥98%
  • L1340

    LDK378

    ALK and IGF-1R inhibitor.

    ≥99%
  • P3456

    Pimobendan

    PDE3 inhibitor.

    ≥99%
  • C9677

    Cyclocytidine Hydrochloride

    Pyrimidine nucleoside analog; DNA synthesis inh...

    ≥98%
  • C0172

    Carbimazole

    Methimazole prodrug; thyroid peroxidase inhibit...

    ≥98%
  • K7602

    KT5823

    PKG inhibitor.

    ≥98%
  • B1977

    Betulin

    Pentacyclic triterpene found in various plant s...

    ≥98%
  • R3206

    Riboflavin

    Essential vitamin (B2) found in vegetables, dai...

    ≥97%
  • N1755

    Neomycin Sulfate

    Polycationic aminoglycoside; protein translatio...

    ≥98%
  • V7200

    VS-5584

    PI3K inhibitor.

    ≥98%
  • H000051

    H-151

    STING antagonist

    ≥99%
  • H9712

    (E)-4-Hydroxytamoxifen

    SERM.

    ≥97%
  • A4497

    Alyssin Sulfone

    Naturally sourced ITC, sulfonyl analog of sulfo...

    ≥97%
  • T3197

    L-Thyroxine Sodium Pentahydrate

    Endogenous thyroid hormone T4.

    ≥97%
  • E5569

    Enramycin B

    Polypeptide; peptidoglycan inhibitor.

    ≥83%
  • O4533

    Oligomycin

    Mixture of oligomycins A, B, C; oxidative phosp...

    ≥97%
  • D564088

    10-Acetyl Docetaxel

    Docetaxel impurity

    ≥98%