LKT Labs

Biochemicals for Life Science Research

Norfloxacin Nicotinate

Norfloxacin Nicotinate

Product ID N5769
Cas No. 118803-81-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $50.90 In stock
10 g $142.90 In stock
50 g $459.60 In stock
Bulk Quote

Quicklinks

Description

Norfloxacin is a first generation fluoroquinolone antibiotic that exhibits antibacterial, anti-inflammatory, and anticancer activities. Norfloxacin inhibits DNA gyrase and topoisomerase IV; it is clinically used to treat urinary tract infections and prostatitis. In neutrophils from cirrhotic subjects, norfloxacin increases expression of IL-10 and heme oxygenase 1 (HO-1) and decreases expression of pro-inflammatory cytokines. Additionally, when complexed with gold(III), norfloxacin binds DNA and inhibits cellular proliferation in several cancer cell lines.

Product Info

Cas No.

118803-81-9
Purity

≥98%
Formula

C16H18FN3O3 • C6H5NO2
Formula Wt.

442.44
IUPAC Name

1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;pyridine-3-carboxylic acid
Melting Point

220-227°C
Solubility

Soluble in water.

Appearance

White/Slight Yellow Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

N5769 MSDS PDF
Info Sheet

N5769 Info Sheet PDF

References

Gouvea LR, Garcia LS, Lachter DR, et al. Atypical fluoroquinolone gold(III) chelates as potential anticancer agents: relevance of DNA and protein interactions for their mechanism of action. Eur J Med Chem. 2012 Sep;55:67-73. PMID: 22835721.

Gómez-Hurtado I, Zapater P, Bellot P, et al. Interleukin-10-mediated heme oxygenase 1-induced underlying mechanism in inflammatory down-regulation by norfloxacin in cirrhosis. Hepatology. 2011 Mar;53(3):935-44. PMID: 21374664.

Padeĭskaia EN. Norfloxacin: more than 20 years of clinical use, the results and place among fluoroquinolones in modern chemotherapy for infections. Antibiot Khimioter. 2003;48(9):28-36. PMID: 15002177.

Drlica K, Zhao X. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. PMID: 9293187.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C0020

    Cafestol

    Diterpene found in brewed, unfiltered coffee; F...

    ≥98%
  • G5216

    GNE-7915

    LRRK2 inhibitor.

    ≥98%
  • N7208

    NSC-74859

    STAT3 inhibitor.

    ≥98%
  • B3358

    Biochanin A

    Phytoestrogen, flavonoid found in clover, soy, ...

    ≥98%
  • M5752

    Monastrol

    Pyrimidine derivative; kinesin Eg5 inhibitor.

    ≥95%
  • F1853

    Fenofibrate

    Fibrate; PPARα agonist.

    ≥98%
  • D3353

    Diminazene Aceturate

    Diamidine; ACE2 activator, DNA polymerase inhib...

    ≥98%
  • C9881

    Cytochalasin D

    Mycotoxin produced by Aspergillus; actin polyme...

    ≥98%
  • Z4552

    ZLN005

    PPARγ coactivator-1α expression stimulator.

    ≥98%
  • R5894

    Roxatidine Acetate Hydrochloride

    Histamine H2 antagonist.

    ≥98%
  • P7218

    Pseudoprotodioscin

    Steroidal saponin found in Tribulus, Trigonella...

    ≥98%
  • C0169

    Carbenoxolone Disodium

    Synthetic derivative of glycyrrhizin; connexin ...

    ≥97%
  • L493400

    LMK-235

    Selective HDAC4 and HDAC5 inhibitor.

    ≥98%
  • A454470

    L-Allylglycine

    Inhibitor of glutamic acid decarboxylase (GAD)....

    ≥98%
  • R3321

    Rifaximin

    Rifampicin derivative; DNA-dependent RNA polyme...

    ≥98%
  • C4418

    Clemizole Hydrochloride

    TRPC5, NS4B, histamine H1 inhibitor.

    ≥98%
  • R8206

    Rubescensin A

    Diterpene originally found in Rabdosia.

    ≥93%
  • L5749

    Lomefloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • S0033

    Saikosaponin B2

    Saponin found in Bupleurum, Heteromorpha, and S...

    ≥98%
  • P2513

    Phenyl Isothiocyanate

    ITC found in cruciferous vegetables.

    ≥98%