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NVP-TAE684

NVP-TAE684

Product ID N8760
Cas No. 761439-42-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $102.30 In stock
5 mg $194.40 In stock
10 mg $295.40 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

NVP-TAE684 is an inhibitor of anaplastic lymphoma kinase (ALK), c-Fes, and LRRK2 that exhibits anticancer chemotherapeutic activity. NVP-TAE684 induces apoptosis in and inhibits growth of diffuse large B-cell lymphoma cells; in animal models, it induces tumor regression. NVP-TAE684 also induces cell cycle arrest and apoptosis in animal models of anaplastic large-cell lymphoma, preventing lymphomagenesis and inducing regression.

Product Info

Cas No.

761439-42-3

Purity

≥98%

Formula

C30H40ClN7O3S

Formula Wt.

614.21

IUPAC Name

5-Chloro-N4-[2-(isopropylsulfonyl)phenyl]-N2-{2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl}-2,4-pyrimidinediamine

Synonym

TAE684

Solubility

DMSO 3 mg/mL (4.88 mM) Water Insoluble Ethanol Insoluble

Appearance

Yellow to pale yellow powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

N8760 MSDS PDF

Info Sheet

N8760 Info Sheet PDF

References

Hellwig S, Miduturu CV, Kanda S, et al. Small-molecule inhibitors of the c-Fes protein-tyrosine kinase. Chem Biol. 2012 Apr 20;19(4):529-40. PMID: 22520759.

Zhang J, Deng X, Choi HG, et al. Characterization of TAE684 as a potent LRRK2 kinase inhibitor. Bioorg Med Chem Lett. 2012 Mar 1;22(5):1864-9. PMID: 22335897.

Cerchietti L, Damm-Welk C, Vater I, et al. Inhibition of anaplastic lymphoma kinase (ALK) activity provides a therapeutic approach for CLTC-ALK-positive human diffuse large B cell lymphomas. PLoS One. 2011 Apr 8;6(4):e18436. PMID: 21494621.

Galkin AV, Melnick JS, Kim S, et al. Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):270-5. Erratum in: Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):2025. PMID: 17185414.

Custom Order

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