• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Oridonin

Oridonin

Product ID O6932
Cas No. 28957-04-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $92.00 In stock
25 mg $306.20 In stock
100 mg $913.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Oridonin is a diterpenoid found in Rabdosia rubescens. Oridonin has anti-inflammatory and antibacterial activity but is most widely known for its anticancer chemotherapeutic actions. This compound can bind HPS70 1A and can fit into the DNA double helix, provoking p53-mediated G2/M cell cycle arrest, apoptosis, and autophagy; these effects inhibit tumor growth in a wide variety of cell lines.

Product Info

Cas No.

28957-04-2

Purity

≥98%

Formula

C20H28O6

Formula Wt.

364.43

Chemical Name

7a,20-Epoxy-1a,6b,7,14-tetrahydroxy-Kaur-16-en-15-one

IUPAC Name

(1S,2S,5S,8R,9S,10S,11R,15S,18R)-9,10,15,18-tetrahydroxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-7-one

Synonym

Isodonol, Rubescensin A (high purity)

Solubility

DMSO 72 mg/mL (197.56 mM) Ethanol 28 mg/mL (76.83 mM) Water Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

O6932 MSDS PDF

Info Sheet

O6932 Info Sheet PDF

References

Hwang T, Chang C. Oridonin enhances cytotoxic activity of natural killer cells against lung cancer. Int Immunopharmacol. 2023 Sep;122:110669. PMID: 37480753.

Chen Z, Wang Z, Chen J, et al. Resonance light scattering technique as a new tool to determine the binding mode of anticancer drug oridonin to DNA. Eur J Med Chem. 2013 Aug;66:380-7. PMID: 23827178.

Dal Piaz F, Cotugno R, Lepore L, et al. Chemical proteomics reveals HSP70 1A as a target for the anticancer diterpene oridonin in Jurkat cells. J Proteomics. 2013 Apr 26;82:14-26. PMID: 23416714.

Yin B, Sheng H, Lin J, et al. The cell death of C6 astrocytoma cells induced by oridonin and its mechanism. Int J Clin Exp Pathol. 2012;5(6):562-8. PMID: 22949939.

Li X, Li X, Wang J, et al. Oridonin up-regulates expression of P21 and induces autophagy and apoptosis in human prostate cancer cells. Int J Biol Sci. 2012;8(6):901-12. PMID: 22745580.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A971336

    Azilsartan Medoxomil

    Prodrug

    ≥98%
  • Z0222

    Zafirlukast

    VEGF-C/Nrp2 inhibitor. Leukotriene receptor ant...

    ≥98%
  • K1676

    Ketoconazole

    Imidazole; 14-α demethylase inhibitor.

    ≥98%
  • T1778

    2,3,5,6-Tetramethylpyrazine

    Dihydropyrazine found in Ligusticum walliichi. ...

    ≥98%
  • C4517

    Clenbuterol Hydrochloride

    β2-adrenergic agonist.

    ≥98%
  • X0384

    XAV-939

    Tankyrase inhibitor.

    ≥98%
  • B3577

    Bitertanol

    Pesticide; demethylation inhibitor.

    ≥98%
  • I6804

    Irbesartan

    PPARγ agonist, AT1 inhibitor.

    ≥98%
  • R2810

    Recombinant Multi-epitope Chimeric HIV Antigen 1

    Recombinant HIV-1 multi-epitope chimeric antige...

    ≥95%
  • A9818

    Azelastine Hydrochloride

    TRPV1 agonist, histamine H1 antagonist.

    ≥98%
  • A5162

    Amprolium Hydrochloride

    Thiamine, coccidiostat; thiamine transporter in...

    ≥97%
  • A0921

    N-Acetyl-D-Leucine

    D-amino acid, incorporated into bacterial cell ...

    ≥98%
  • A5472

    Ansamitocin P3

    Microtubule depolymerization inhibitor.

    ≥70% (P3), Total Ansamitocins ≥95%
  • S1061

    Small Cardioactive Peptide B

    Peptide found in molluscs, cardiomodulator.

    ≥95%
  • B8112

    Budesonide

    Steroid; glucocorticoid agonist.

    ≥97%
  • B8176

    2-n-Butylthiophene

    Sulfur analog of furan found in cooked meat pro...

    ≥98%
  • C6019

    C-Peptide, human

    Endogenous peptide, connects A and B chains of ...

    ≥95%
  • D0368

    2-Epi-16-deoxysarcophine

    Cembranoid found in Sarcophyton.

    ≥98%
  • S176481

    Semaglutide

    GLP-1 agonist

    ≥95%
  • F3206

    Fibrinolysis Inhibiting Factor

    Peptide; fibrinolysis inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only