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Oridonin

Oridonin

Product ID O6932
Cas No. 28957-04-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $92.00 In stock
25 mg $306.20 In stock
100 mg $913.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Oridonin is a diterpenoid found in Rabdosia rubescens. Oridonin has anti-inflammatory and antibacterial activity but is most widely known for its anticancer chemotherapeutic actions. This compound can bind HPS70 1A and can fit into the DNA double helix, provoking p53-mediated G2/M cell cycle arrest, apoptosis, and autophagy; these effects inhibit tumor growth in a wide variety of cell lines.

Product Info

Cas No.

28957-04-2

Purity

≥98%

Formula

C20H28O6

Formula Wt.

364.43

Chemical Name

7a,20-Epoxy-1a,6b,7,14-tetrahydroxy-Kaur-16-en-15-one

IUPAC Name

(1S,2S,5S,8R,9S,10S,11R,15S,18R)-9,10,15,18-tetrahydroxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-7-one

Synonym

Isodonol, Rubescensin A (high purity)

Solubility

DMSO 72 mg/mL (197.56 mM) Ethanol 28 mg/mL (76.83 mM) Water Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

O6932 MSDS PDF

Info Sheet

O6932 Info Sheet PDF

References

Hwang T, Chang C. Oridonin enhances cytotoxic activity of natural killer cells against lung cancer. Int Immunopharmacol. 2023 Sep;122:110669. PMID: 37480753.

Chen Z, Wang Z, Chen J, et al. Resonance light scattering technique as a new tool to determine the binding mode of anticancer drug oridonin to DNA. Eur J Med Chem. 2013 Aug;66:380-7. PMID: 23827178.

Dal Piaz F, Cotugno R, Lepore L, et al. Chemical proteomics reveals HSP70 1A as a target for the anticancer diterpene oridonin in Jurkat cells. J Proteomics. 2013 Apr 26;82:14-26. PMID: 23416714.

Yin B, Sheng H, Lin J, et al. The cell death of C6 astrocytoma cells induced by oridonin and its mechanism. Int J Clin Exp Pathol. 2012;5(6):562-8. PMID: 22949939.

Li X, Li X, Wang J, et al. Oridonin up-regulates expression of P21 and induces autophagy and apoptosis in human prostate cancer cells. Int J Biol Sci. 2012;8(6):901-12. PMID: 22745580.

Custom Order

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