LKT Labs

Biochemicals for Life Science Research

Pazopanib

Product ID P0397
Cas No. 444731-52-6
Purity ≥97%
Product Unit SizeCostQuantityStock
5 mg $40.50 In stock
25 mg $86.80 In stock
100 mg $214.20 In stock
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Description

Pazopanib is an inhibitor of VEGFR, PDGFR, and c-Kit that displays anticancer chemotherapeutic and anti-angiogenic activities. Pazopanib is clinically used to treat metastatic renal cell carcinoma, but shows potential for a wide variety of other cancers, including ovarian cancer and non-small cell lung cancer (NSCLC). In vitro and in vivo, pazopanib inhibits cell proliferation and angiogenesis, preventing tumor growth. This compound also inhibits wild-type B-Raf, preventing activation of p-ERK1/2 and p-MEK1/2, decreasing brain metastasis volume in animal models of breast cancer.

Product Info

Cas No.

444731-52-6
Purity

≥97%
Formula

C21H23N7O2S
Formula Wt.

437.53
Chemical Name

5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide
IUPAC Name

5-[[4-[(2, 3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2- methylbenzenesulfonamide
Synonym

GSK-VEG10003; GW786034B; GW-786034
Melting Point

301-313°C
Appearance

Off-white crystalline powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

P0397 MSDS PDF
Info Sheet

P0397 Info Sheet PDF
Brochures

Ras-Raf-MEK-ERK Pathway Booklet

References

Pick AM, Nystrom KK. Pazopanib for the treatment of metastatic renal cell carcinoma. Clin Ther. 2012 Mar;34(3):511-20. PMID: 22341567.

Gril B, Palmieri D, Qian Y, et al. Pazopanib reveals a role for tumor cell B-Raf in the prevention of HER2+ breast cancer brain metastasis. Clin Cancer Res. 2011 Jan 1;17(1):142-53. PMID: 21081656.

Hamberg P, Verweij J, Sleijfer S. (Pre-)clinical pharmacology and activity of pazopanib, a novel multikinase angiogenesis inhibitor. Oncologist. 2010;15(6):539-47. PMID: 20511320.

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