LKT Labs

Biochemicals for Life Science Research

Penicillamine

Penicillamine

Product ID P1753
Cas No. 52-67-5
Purity ≥97%
Product Unit SizeCostQuantityStock
1 g $48.50 In stock
5 g $155.70 In stock
25 g $583.50 In stock
Bulk Quote

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Description

Penicillamine is a penicillin derivative that does not exhibit antibiotic activity. Penicillamine is a chelating compound that is clinically used to treat rheumatoid arthritis; it exhibits immunosuppressive, anti-inflammatory, and anti-allergic activities. In vitro, penicillamine decreases expression of IL-1, cross-linking of collagen, and activity of macrophages; it also decreases overall T cell levels. Penicillamine also inhibits carboxypeptidases and separately, decreases allergen-induced production of immunoglobulins.

Product Info

Cas No.

52-67-5
Purity

≥97%
Formula

C5H11NO2S
Formula Wt.

149.21
Chemical Name

3-Mercapto-D-valine
IUPAC Name

(2S)-2-amino-3-methyl-3-sulfanylbutanoic acid
Synonym

Cuprimine, Depen, DMC, D-Penamine, Mercaptyl, Pendramine, Sufortan, Trolovol
Melting Point

202-206°C
Solubility

Soluble in water. Slightly soluble in alcohol. Insoluble in ether, acetone, benzene, and carbon tetrachloride.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

P1753 MSDS PDF
Info Sheet

P1753 Info Sheet PDF

References

Chong CR, Auld DS. Inhibition of carboxypeptidase A by D-penicillamine: mechanism and implications for drug design. Biochemistry. 2000 Jun 27;39(25):7580-8. PMID: 10858308.

Meyer O. D-penicillamine: mechanism of cellular action and induced autoimmune diseases. Rev Rhum Mal Osteoartic. 1986 Jan;53(1):15-20. PMID: 2939541.

Camp AV. Penicillamine in the treatment of rheumatoid arthritis. Proc R Soc Med. 1977 Feb;70(2):67-9. PMID: 859814.

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