Description
Pepstatin is a peptide originally found in Actinomyces; it inhibits aspartyl proteases such as pepsin and cathepsins D and E. Pepstatin may inhibit RANKL-induced osteoclast differentiation and phosphorylation of ERK.
Pepstatin
Product ID P1761
Cas No. 26305-03-3
Purity ≥98%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 26305-03-3 |
|---|---|
| Purity | ≥98% |
| Formula | C34H63N5O9 |
| Formula Wt. | 685.89 |
| Chemical Name | L-Alaninamide, N-(3-methyl-1-oxobutyl)-L-valyl-(3S,4S)-4- amino-3-hydroxy-6-methylheptanoyl-N-((1S)-1-((1S)-2-carboxy-1-hydroxyethyl)-3-methylbutyl)- |
| IUPAC Name | (3S, 4S)-3-hydroxy-4-[[(2S)-2-[[(3S)-3-hydroxy-6-methyl-4-[[3-methyl-2-[[3- methyl-2-(3-methylbutanoylamino)butanoyl]amino]butanoyl]amino]heptanoyl] amino]propanoyl]amino]-6-methylheptanoic acid |
| Synonym | Pepstatin A |
| Melting Point | 228-229°C |
| Solubility | Soluble in methanol, ethanol or DMSO. |
| Appearance | White powder |
Shipping and Storage
| Store Temp | 4°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Marciniszyn J Jr, Hartsuck JA, Tang J. Mode of inhibition of acid proteases by pepstatin. J Biol Chem. 1976 Nov 25;251(22):7088-94. PMID: 993206.
Umezawa H, Aoyagi T, Morishima H, et al. Pepstatin, a new pepsin inhibitor produced by Actinomycetes. J Antibiot (Tokyo). 1970 May;23(5):259-62. PMID: 4912600.