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(-)-Pinostrobin is a naturally occurring flavonoid isolated from Lindera reflexa Hemsl (山橿), and many other variety of plants. Its bioactivities include antioxidant, anti-inflammatory anticancer, and neuroprotective properties. Pinostrobin inhibits malignant breast epithelial cell adhesion and focal adhesion formation to attenuate cell migration and induces apoptosis in human cervical cancer cells.
| Cas No. | 480-37-5 |
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| Purity | ≥99% |
| Formula | C16H14O4 |
| Formula Wt. | 270.28 |
| Chemical Name | (2S)-5-Hydroxy-7-methoxy-2-phenyl-2,3-dihydro-4H-chromen-4-one |
| IUPAC Name | (2S)-5-Hydroxy-7-methoxy-2-phenyl-2,3-dihydro-4H-chromen-4-one |
| Synonym | 5-Hydroxy-7-methoxyflavanone; 5-hydroxy-7-methoxy-2-phenylchroman-4-one; Pinostrombin; Pinocembrin-7-methylether; (2S)-pinostrobin |
| Appearance | White powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
N K Patel, G Jaiswal, and K K Bhutani, A review on biological sources, chemistry and pharmacological activities of pinostrobin, Nat Prod Res. 30:2017-27, 2016. PMID: 26653796 DOI: 10.1080/14786419.2015.1107556.
W Y Gao, P-Y Chen, S F Chen, et al. Pinostrobin Inhibits Proprotein Convertase Subtilisin/Kexin-type 9 (PCSK9) Gene Expression through the Modulation of FoxO3a Protein in HepG2 Cells. J Agric Food Chem. 66:6083-6093, 2018. PMID: 29862818 DOI: 10.1021/acs.jafc.8b02559
A A Jones and S Gehler, Acacetin and Pinostrobin Inhibit Malignant Breast Epithelial Cell Adhesion and Focal Adhesion Formation to Attenuate Cell Migration, Integr Cancer Ther. 19:1534735420918945, 2020. PMID: 32493139 Free PMC article, PMCID: PMC7273556, DOI: 10.1177/1534735420918945.
A Jaudan, S Sharma, S N A Malek, et al, Induction of apoptosis by pinostrobin in human cervical cancer cells: Possible mechanism of action, PLoS One. 13:e0191523, 2018. PMID: 29420562, PMCID: PMC5805241, DOI: 10.1371/journal.pone.0191523