LKT Labs

Biochemicals for Life Science Research

Pioglitazone Hydrochloride

Product ID P6954
Cas No. 112529-15-4
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $52.50 In stock
500 mg $149.90 In stock
1 g $224.70 In stock
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Description

Pioglitazone is a thiazolidinedione that acts as an agonist at PPARα/γ receptors and also binds mitoNEET, a mitochondrial protein involved in energy homeostasis. Pioglitazone exhibits anti-diabetic, antacid, antidepressant, antinociceptive, and anti-diarrheal activities. In vivo, pioglitazone decreases levels of HDL, triglycerides, total cholesterol, insulin, blood glucose, and Hb1Ac. Pioglitazone may also have effects on angiogenesis, decreasing expression of HIF-1α and VEGF but increasing microvessel density in animal models of hind limb ischemia. This compound inhibits formation of ulcers in vivo potentially due to inhibition of IL-1β and iNOS and induction of cNOS. Additionally, pioglitazone decreases visceral hypersensitivity, suppresses defecation, and increases nociceptive thresholds in vivo.

Product Info

Cas No.

112529-15-4
Purity

≥98%
Formula

C19H20N2O3S • HCl
Formula Wt.

392.91
Chemical Name

2,4-Thiazolidinedione, 5-((4-(2-(5-ethyl-2- pyridinyl)ethoxy)phenyl)methyl)-, monohydrochloride, (+-)-

IUPAC Name

5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2, 4-dione;hydrochloride
Synonym

Actos, U-72107A.
Melting Point

193-194°C
Solubility

Soluble in DMF, DMSO(79mg/mL). Slightly soluble in ethanol(4mg/mL). acetone or acetonitrile. Practically insoluble in water. Insoluble in ether.

Appearance

White to off-White Crystalline Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

P6954 MSDS PDF
Info Sheet

P6954 Info Sheet PDF

References

Zhang M, Gao X, Bai SJ, et al. Effect of pioglitazone on expression of hypoxia-inducible factor 1α and vascular endothelial growth factor in ischemic hindlimb of diabetic rats. Eur Rev Med Pharmacol Sci. 2014;18(9):1307-14. PMID: 24867508.

Kemp DE, Schinagle M, Gao K, et al. PPAR-γ agonism as a modulator of mood: proof-of-concept for pioglitazone in bipolar depression. CNS Drugs. 2014 Jun;28(6):571-81. PMID: 24715548.

Paragomi P, Rahimian R, Kazemi MH, et al. Antinociceptive and antidiarrheal effects of pioglitazone in a rat model of diarrhoea-predominant irritable bowel syndrome: role of nitric oxide. Clin Exp Pharmacol Physiol. 2014 Feb;41(2):118-26. PMID: 24471407.

Moezi L, Heidari R, Amirghofran Z, et al. Enhanced anti-ulcer effect of pioglitazone on gastric ulcers in cirrhotic rats: the role of nitric oxide and IL-1β. Pharmacol Rep. 2013;65(1):134-43. PMID: 23563031.

Paddock ML, Wiley SE, Axelrod HL, et al. MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14342-7. PMID: 17766440.

Gillies PS, Dunn CJ. Pioglitazone. Drugs. 2000 Aug;60(2):333-43; PMID: 10983737.

Yoshida H, Watanabe W, Oomagari H, et al. Citrus flavonoid naringenin inhibits TLR2 expression in adipocytes. J Nutr Biochem. 2013 Jul;24(7):1276-1284. PMID: 23333096.

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