• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
PLX4720

PLX4720

Product ID P4492
Cas No. 918505-84-7
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $132.60 In stock
25 mg $368.20 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

PLX4720 is an orally available ATP-competitive kinase inhibitor specific for mutant (V600E) B-Raf, which is present in a variety of cancer subtypes. PLX4720 is an analog of vemurafenib. This compound is being examined as a treatment for unresectable or metastatic melanomas. Inhibition of B-Raf by PLX4720 induces apoptosis and autophagy in tumor cells, resulting in decreased tumor growth and increased survival in vitro and in vivo. Additional downstream effects of B-Raf inhibition by PLX4720 include downregulation of expression of angiogenic factors, enhancement of surface expression of tumor-associated antigens on tumor cells, and alterations of trafficking of local immune cells such as CD8+ T lymphocytes.

Product Info

Cas No.

918505-84-7

Purity

≥98%

Formula

C17H14ClF2N3O3S

Formula Wt.

413.83

Chemical Name

N-[3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2, 4-difluorophenyl]propane-1-sulfonamide

IUPAC Name

N-[3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2, 4-difluorophenyl]propane-1-sulfonamide

Synonym

PLX-4720

Solubility

DMSO 83 mg/mL (200.56 mM) Water Insoluble Ethanol Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P4492 MSDS PDF

Info Sheet

P4492 Info Sheet PDF

References

Liu C, Peng W, Xu C, et al. BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice. Clin Cancer Res. 2013 Jan 15;19(2):393-403. PMID: 23204132.

Bottos A, Martini M, Di Nicolantonio F, et al. Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):E353-9. PMID: 22203991.

Wilmott JS, Long GV, Howle JR, et al. Selective BRAF inhibitors induce marked T-cell infiltration into human metastatic melanoma. Clin Cancer Res. 2012 Mar 1;18(5):1386-94. PMID: 22156613.

Boni A, Cogdill AP, Dang P, et al. Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function. Cancer Res. 2010 Jul 1;70(13):5213-9. PMID: 20551059.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A761003

    AT-7519 Hydrochloride

    ATP competitive CDK inhibitor.

    ≥98%
  • C2970

    Chrysophanol

    Anthraquinone found in Rheum.

    ≥98%
  • A5135

    Aminophylline Dihydrate

    Xanthine derivative; adenosine antagonist, PDE ...

    ≥98%
  • C016481

    Camalexin

    Phytoalexin

    ≥98%
  • C5863

    Coptisine Chloride, natural

    Isoquinoline alkaloid found in a variety of pla...

    ≥98%
  • A1333

    Adipokinetic Hormone II from Schistocera gregaria

    Neuropeptide found in Schistocera gregaria.

    ≥95%
  • B3573

    Bisdemethoxycurcumin

    Curcumin derivative; DNMT1 and α-amylase inhib...

    ≥98%
  • E5575

    Entacapone

    COMT inhibitor.

    ≥98%
  • M3321

    Mifepristone

    Synthetic steroid, contraceptive; PR and glucoc...

    ≥98%
  • V3213

    Vidarabine Monophosphate

    Nucleoside (adenosine) analog found in Tethyra ...

    ≥98.0%
  • T8004

    Tubeimoside I

    Triterpene saponin originally found in Bolboste...

    ≥96%
  • T7034

    Trimethoprim

    Dihydrofolate reductase inhibitor.

    ≥98%
  • R1780

    trans-Retinoic Acid

    Vitamin A carboxylic acid; RAR agonist.

    ≥98%
  • P6870

    Propofol

    GABA-A agonist, NMDA antagonist, voltage-gated ...

    ≥98%
  • I7074

    Irsogladine Maleate

    NSAID; COX-1/2 and PDE inhibitor.

    ≥98%
  • T1672

    Terbinafine Hydrochloride

    Allylamine; squalene oxidase and KSR1 inhibitor...

    ≥98%
  • C0160

    Canrenone

    Metabolite of spironolactone; Na+/K+ ATPase par...

    ≥98%
  • P2303

    Phallacidin

    Phallotoxin found in Amanita phalloides; microt...

    ≥98%
  • T5847

    Tolvaptan

    V2 antagonist.

    ≥99%
  • C3352

    Cinacalcet Hydrochloride

    Ca2+-sensing receptor agonist.

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only