Description
Pterostilbene is a methylated analog of resveratrol; it exhibits antioxidative, anticancer, anti-metastatic, and anxiolytic properties. This compound inhibits DNA strand breaks induced by DPPH, superoxide, and hydrogen peroxide in cellular models. Also in vitro, pterostilbene inhibits tumor sphere formation, cellular migration and invasion and increases apoptosis, potentially through suppression of NF-κB and metastasis-associated protein 1. Additionally, pterostilbene downregulates ERK signaling in the hippocampus in animal models, resulting in increased open arm entries in an elevated plus maze.