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Pyrantel pamoate is a mixture of pyrantel, a thiophene, and pamoic acid. This combination exhibits anti-parasitic/anti-helminthic activities. Pyrantel pamoate acts as a depolarizing neuromuscular junction blocker, activating nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction and inducing muscular paralysis. Pyrantel pamoate is used to treat worm infections in humans and animals.
| Cas No. | 22204-24-6 |
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| Purity | ≥98% |
| Formula | C23H16O6 • C11H14N2S |
| Formula Wt. | 594.68 |
| Chemical Name | (E)-1,4,5,6-Tetrahydro-1-methyl-2-[2-(2-thienyl)- ethenyl]pyrimidine pamoate |
| IUPAC Name | 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2- carboxylic acid;1-methyl-2-[(E)-2-thiophen-2-ylethenyl]-5,6-dihydro-4H-pyrimidine |
| Synonym | Pyrantel embonate, Antiminth, Cobantril, Early bird, Helmex, Piranver |
| Melting Point | 266-267°C |
| Solubility | Insoluble in water. |
| Appearance | Yellow to Tan Solid |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
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| Info Sheet |
Reinemeyer CR, Hutchens DE, Eckblad WP, et al. Dose-confirmation studies of the cestocidal activity of pyrantel pamoate paste in horses. Vet Parasitol. 2006 Jun 15;138(3-4):234-9. PMID: 16530970.
Clark JN, Daurio CP, Plue RE, et al. Efficacy of ivermectin and pyrantel pamoate combined in a chewable formulation against heartworm, hookworm, and ascarid infections in dogs. Am J Vet Res. 1992 Apr;53(4):517-20. PMID: 1586021.