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Raltitrexed

Raltitrexed

Product ID R0245
Cas No. 112887-68-0
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $125.80 In stock
25 mg $251.50 In stock
100 mg $754.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Raltitrexed is a quinazoline analog of folate. Raltitrexed acts as an antifolate anticancer chemotherapeutic, inhibiting thymidylate synthase. Raltitrexed disrupts DNA synthesis and induces strand breaks. This compound is approved in some countries for the treatment of advanced colorectal cancer.

Product Info

Cas No.

112887-68-0

Purity

≥98%

Formula

C21H22N4O6S

Formula Wt.

458.49

Chemical Name

(2S)-2-[[5-[methyl-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl]amino]thiophene-2-carbonyl]amino]pentanedioic acid

IUPAC Name

(2S)-2-[[5-[methyl-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl]amino] thiophene-2-carbonyl]amino]pentanedioic acid

Melting Point

180-184°C

Appearance

White to light yellow powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

R0245 MSDS PDF

Info Sheet

R0245 Info Sheet PDF

References

Avallone A, Gennaro ED, Silvestro L, et al. Targeting thymidylate synthase in colorectal cancer: critical re-evaluation and emerging therapeutic role of raltitrexed. Expert Opin Drug Saf. 2014 Jan;13(1):113-29. PMID: 24093908.

Van Cutsem E, Cunningham D, Maroun J, et al. Raltitrexed: current clinical status and future directions. Ann Oncol. 2002 Apr;13(4):513-22. PMID: 12056700.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

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