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RG-108

RG-108

Product ID R2400
Cas No. 48208-26-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $90.30 In stock
10 mg $157.80 In stock
25 mg $330.60 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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  • Downloads
  • References
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Description

RG-108 is an inhibitor of DNA methyltransferases (DNMTs) that exhibits antidepressant, neuromodulatory, anticancer, and antiepileptic activities. RG-108 attenuates stress-induced behavioral adaptations in animal models and inhibits persistent epileptiform activity. RG-108 also increases TERT expression. In prostate cancer cells, this compound induces apoptosis and inhibits cell growth.

Product Info

Cas No.

48208-26-0

Purity

≥98%

Formula

C19H14N2O4

Formula Wt.

334.33

Chemical Name

N-Phthalyl-L-tryptophan

IUPAC Name

(2S)-2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid

Solubility

DMSO 67 mg/mL (200mM) Ethanol 67 mg/mL (200mM) Water Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

R2400 MSDS PDF

Info Sheet

R2400 Info Sheet PDF

References

Sales AJ, Joca SR. Effects of DNA methylation inhibitors and conventional antidepressants on mice behaviour and brain DNA methylation levels. Acta Neuropsychiatr. 2015 Jun 26:1-12. PMID: 26112212.

Oh YS, Jeong SG, Cho GW. Anti-senescence effects of DNA methyltransferase inhibitor RG108 in human bone marrow mesenchymal stromal cells. Biotechnol Appl Biochem. 2015 May 8. [Epub ahead of print]. PMID: 25952632.

Graça I, Sousa EJ, Baptista T, et al. Anti-tumoral effect of the non-nucleoside DNMT inhibitor RG108 in human prostate cancer cells. Curr Pharm Des. 2014;20(11):1803-11. PMID: 23888969.

Machnes ZM, Huang TC, Chang PK, et al. DNA methylation mediates persistent epileptiform activity in vitro and in vivo. PLoS One. 2013 Oct 2;8(10):e76299. PMID: 24098468.

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