LKT Labs

Biochemicals for Life Science Research

(S)-CR8

Product ID C6801
Cas No. 1084893-56-0
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $128.60 Please Inquire
5 mg $385.90 Please Inquire
Bulk Quote

Quicklinks

Description

(S)-CR8 is an analog of roscovitine that inhibits cyclin-dependent kinases (CDKs) 1/2/3/5/7/9; it displays anticancer, nephroprotective, and neuroprotective activities. CR8 induces apoptosis in various cancer cells by suppressing cell cycle progression. In animal models of spinal cord injury, this compound decreases neurodegeneration, cognitive decline, and microglial activation. CR8 also decreases sensorimotor deficits, cognitive deficits, and lesion volume by limiting cell cycle activation in animal models of traumatic brain injury. In animal models of polycystic kidney disease, (S)-CR8 decreases renal and hepatic cystogenesis and attenuates kidney function decline by suppressing cell cycle progression and decreasing apoptosis.

Product Info

Cas No.

1084893-56-0
Purity

≥99%
Formula

C24H29N7O
Formula Wt.

431.54
Chemical Name

(2S)-2-[(9-Isopropyl-6-{[4-(2-pyridinyl)benzyl]amino}-9H-purin-2-yl)amino]-1-butanol
IUPAC Name

(2S)-2-[(9-Isopropyl-6-{[4-(2-pyridinyl)benzyl]amino}-9H-purin-2-yl)amino]-1-butanol
Synonym

2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine
Solubility

Soluble in DMSO or ethanol
Appearance

White to off-white solid.

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

C6801 MSDS PDF
Info Sheet

C6801 Info Sheet PDF

References

Wu J, Zhao Z, Sabirzhanov B, et al. Spinal cord injury causes brain inflammation associated with cognitive and affective changes: role of cell cycle pathways. J Neurosci. 2014 Aug 13;34(33):10989-1006. PMID: 25122899.

Kabadi SV, Stoica BA, Loane DJ, et al. CR8, a novel inhibitor of CDK, limits microglial activation, astrocytosis, neuronal loss, and neurologic dysfunction after experimental traumatic brain injury. J Cereb Blood Flow Metab. 2014 Mar;34(3):502-13. PMID: 24398934.

Bukanov NO, Moreno SE, Natoli TA, et al. CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD. Cell Cycle. 2012 Nov 1;11(21):4040-6. PMID: 23032260.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.