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Schisantherin A

Schisantherin A

Product ID S0930
Cas No. 58546-56-8
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $201.40 In stock
10 mg $330.00 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Schisantherin A is a dibenzocyclooctadiene originally found in Schisandra that exhibits anti-tussive, sedative, anti-inflammatory, anti-osteoporotic, neuroprotective, cognition enhancing, and cardioprotective activities. In macrophages, schisantherin A decreases LPS-induced expression and activity of iNOS, COX-2, NO, IL-6, and TNF-α. Schisantherin A also decreases RANKL-induced NF-κB signaling by inhibiting IκBα degradation and suppressing JNK and ERK1/2 activation in vitro; it also inhibits osteoclast function and bone erosion in vivo. In animal models of Alzheimer’s disease, schisantherin A inhibits amyloid-β (Aβ)-induced learning and memory impairments in Y maze, shuttle box, and Morris water maze assays. Additionally, this compound lowers left ventricular systolic and end diastolic pressures, decreases infarct size and maldionaldehyde release, and increases superoxide dismutase activity, preventing myocardial apoptosis in animal models of cardiac ischemia/reperfusion.

Product Info

Cas No.

58546-56-8

Purity

≥98%

Formula

C30H32O9

Formula Wt.

536.58

IUPAC Name

[(8S,9S,10S)-9-hydroxy-3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaen-8-yl] benzoate

Synonym

Schizantherin A, Gomisin C, Wuweizi ester A

Melting Point

116-118°C

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

S0930 MSDS PDF

Info Sheet

S0930 Info Sheet PDF

References

He Y, Zhang Q, Shen Y, et al. Schisantherin A suppresses osteoclast formation and wear particle-induced osteolysis via modulating RANKL signaling pathways. Biochem Biophys Res Commun. 2014 Jul 4;449(3):344-50. PMID: 24845381.

Li X, Zhao X, Xu X, et al. Schisantherin A recovers Aβ-induced neurodegeneration with cognitive decline in mice. Physiol Behav. 2014 Jun 10;132:10-6. PMID: 24813830.

Chang R, Li Y, Yang X, et al. Protective role of deoxyschizandrin and schisantherin A against myocardial ischemia-reperfusion injury in rats. PLoS One. 2013 Apr 19;8(4):e61590. PMID: 23620773.

Ci X, Ren R, Xu K, et al. Schisantherin A exhibits anti-inflammatory properties by down-regulating NF-kappaB and MAPK signaling pathways in lipopolysaccharide-treated RAW 264.7 cells. Inflammation. 2010 Apr;33(2):126-36. PMID: 20238486.

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