LKT Labs

Biochemicals for Life Science Research

Tolvaptan

Tolvaptan

Product ID T5847
Cas No. 150683-30-0
Purity ≥99%
Product Unit SizeCostQuantityStock
25 mg $108.00 In stock
100 mg $236.00 In stock
500 mg $730.00 In stock
Bulk Quote

Quicklinks

Description

Tolvaptan is an inhibitor of the vasopressin receptor subtype V2; it acts as a diuretic, inhibiting reabsorption of water in the kidney without loss of sodium. Tolvaptan is a clinically effective diuretic used in congestive heart failure (CHF) and severe chronic kidney disease that does not induce hypernatremia. This compound can also be used to treat the severe or chronic hyponatremia stemming from syndrome of inappropriate antidiuretic hormone secretion (SIADH) that occurs after traumatic brain injury.

Product Info

Cas No.

150683-30-0
Purity

≥99%
Formula

C26H25ClN2O3
Formula Wt.

448.94
Chemical Name

N-(4-{[(5R)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-methylphenyl)-2-methylbenzamide
IUPAC Name

N-[4-(7-chloro-5-hydroxy-2,3,4, 5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide
Synonym

OPC-41061
Melting Point

226°C
Appearance

Off-white to yellow powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

T5847 MSDS PDF
Info Sheet

T5847 Info Sheet PDF

References

Otsuka T, Sakai Y, Ohno D, et al. The effects of tolvaptan on patients with severe chronic kidney disease complicated by congestive heart failure. Clin Exp Nephrol. 2013 Mar 13. [Epub ahead of print]. PMID: 23483323.

Graziani G, Cucchiari D, Aroldi A, et al. Syndrome of inappropriate secretion of antidiuretic hormone in traumatic brain injury: when tolvaptan becomes a life saving drug. J Neurol Neurosurg Psychiatry. 2012 May;83(5):510-2. PMID: 22323742

Gheorghiade M, Teerlink JR, Mebazaa A. Pharmacology of new agents for acute heart failure syndromes. Am J Cardiol. 2005 Sep 19;96(6A):68G-73G. PMID: 16181825.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • H966144

    6-Hydroxydopamine Hydrobromide

    Neurotoxin frequently used to aid in modeling P...

    ≥98%
  • P0256

    Pantoprazole Sodium Sesquihydrate

    H+/K+ ATPase and ROCK-2 inhibitor.

    ≥98%
  • T1012

    13-TES-Baccatin III

    Synthesis impurity

    ≥98%
  • L943721

    LXS-196

    Selective inhibitor of protein kinase C (PKC).<...

    ≥98%
  • R3249

    Rimantadine Hydrochloride

    Viral M2 proton channel blocker.

    ≥98%
  • H0142

    Haloperidol

    Butyrophenone; σ2 agonist, α1-adrenergic, D2,...

    ≥95%
  • P0145

    Palmitoyl-D,L-carnitine

    Long chain acylcarnitine involved in fatty acid...

    ≥98%
  • K1676

    Ketoconazole

    Imidazole; 14-α demethylase inhibitor.

    ≥98%
  • I538583

    Inosine

    Adenosine analog

    ≥98%
  • B8377

    5-tert-Butoxyquinazoline-2,4-diamine

    Diaminoquinazoline derivative.

    ≥98%
  • S8012

    [Sar9]-Substance P

    Endogenous tachykinin peptide, involved in infl...

    ≥95%
  • T1006

    10-Acetoacetyl Paclitaxel

    Synthesis impurity

    ≥95%
  • M0262

    Maprotiline Hydrochloride

    Tetracycline; FIASMA, histamine H1, 5-HT2, mACh...

    ≥98%
  • G016499

    2’,3’-cGAMP Sodium Salt

    Agonist of STING.

    ≥99%
  • P465822

    Pluripotin

    Dual kinase and GTPase inhibitor.

    ≥98%
  • T1777

    S,S-(+)-Tetrandrine

    Benzylisoquinoline alkaloid originally found in...

    ≥98%
  • R3012

    Recombinant TpN 17 protein

    Recombinant protein containing Treponema pallid...

    ≥95%
  • O9334

    Oxibendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥98%
  • T0110

    Taxane Standard Mixture

    Mixture of taxanes.

    ≥98%
  • A0802

    Acarbose

    α-glucosidase inhibitor.

    ≥98%