• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Tranilast

Tranilast

Product ID T6902
Cas No. 53902-12-8
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $61.10 In stock
50 mg $132.60 In stock
100 mg $173.70 In stock
500 mg $510.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tranilast is an inhibitor of transient receptor potential vanilloid 2 (TRPV2) channels and PDGFRs; it is also a mast cell stabilizer. Tranilast exhibits anti-allergic, anti-fibrotic, immunomodulatory, anti-angiogenic, anti-metastatic, and anticancer chemotherapeutic activities. In animal models of fibrosis, tranilast inhibits mast cell filtration and decreases levels of α-SMA, collagen I, fibronectin, stem cell factor, and c-kit. In other animal models, this compound decreases allograft rejection and induces T cell anergy by increasing expression of p21 and p51, decreasing levels of IL-2, and stimulating cell cycle arrest. In cellular and animal models of breast cancer, tranilast induces G1/S phase cell cycle arrest, decreases levels of TGF-β1 and endoglin, increases levels of p53 and activation of caspase 3 and PARP, and inhibits cell migration, cell proliferation, and tumor growth. In vitro, tranilast inhibits VEGF- and FGF-induced cell proliferation, migration, and tube formation.

Product Info

Cas No.

53902-12-8

Purity

≥98%

Formula

C18H17NO5

Formula Wt.

327.34

Chemical Name

2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]- amino]benzoic acid

IUPAC Name

2-[[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]benzoic acid

Synonym

Rizaben, N-5'

Melting Point

211-213°C

Solubility

Soluble in DMSO (20 mg/mL), ethanol (2 mg/mL), DMF (35 mg/mL). Insoluble in water.

Appearance

Light yellow green crystal powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T6902 MSDS PDF

Info Sheet

T6902 Info Sheet PDF

References

Luo J, Li Y, Yang Y, et al. Role and mechanism of tranilast preventing the progression of tubulointerstilial fibrosis in diabetic kidney diseases. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 Dec;38(12):1233-42. PMID: 24384948.

Zaher SS, Coe D, Chai JG, et al. Suppression of the allogeneic response by the anti-allergy drug N-(3,4-dimethoxycinnamonyl) anthranilic acid results from T-cell cycle arrest. Immunology. 2013 Feb;138(2):157-64. PMID: 23121382.

Subramaniam V, Chakrabarti R, Prud'homme GJ, et al. Tranilast inhibits cell proliferation and migration and promotes apoptosis in murine breast cancer. Anticancer Drugs. 2010 Apr;21(4):351-61. PMID: 20145538.

Li Y, Liu FY, Peng YM, et al. Mast cell, a promising therapeutic target in tubulointerstitial fibrosis. Med Hypotheses. 2007;69(1):99-103. PMID: 17257770.

Watanabe S, Matsuda A, Suzuki Y, et al. Inhibitory mechanism of tranilast in human coronary artery smooth muscle cells proliferation, due to blockade of PDGF-BB-receptors. Br J Pharmacol. 2000 May;130(2):307-14. PMID: 10807667.

Koyama S, Takagi H, Otani A, et al. Tranilast inhibits protein kinase C-dependent signalling pathway linked to angiogenic activities and gene expression of retinal microcapillary endothelial cells. Br J Pharmacol. 1999 May;127(2):537-45. PMID: 10385256.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C0252

    Canertinib Dihydrochloride

    EGFR inhibitor.

    ≥98%
  • M0173

    Mastoparan X

    Antimicrobial peptide found in bee and wasp ven...

    ≥95%
  • F334453

    Filipin III

    Antifungal antibiotic

    ≥95%
  • M3353

    Minocycline Hydrochloride

    Tetracycline; protein translation inhibitor, MM...

    ≥98%
  • M184776

    5-(Methylsulfonyl)pentyl Nitrile

    Synthetic nitrile compound

    ≥98%
  • U0618

    Ubenimex

    Dipeptide; aminopeptidase (N/CD13) inhibitor.

    ≥98%
  • L3561

    D,L-α-Lipoic Acid

    Endogenous organosulfur also found in meat and ...

    ≥99%
  • D1872

    Des(benzylpyridyl) Atazanavir

    Atazanavir metabolite; HIV protease inhibitor.<...

    ≥98%
  • H1893

    Hexarelin

    Synthetic ghrelin analog; ghrelin agonist.

    ≥95%
  • O4104

    Okadaic Acid Sodium

    Shellfish toxin produced by dinoflagellates and se...
    ≥98%
  • N800000

    NU-2058

    CDK1/2 inhibitor.

    ≥98%
  • A0966

    Adrenocorticotropic Hormone (1-16), human

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • V1854

    Venlafaxine Hydrochloride

    SERT, NET, MAO inhibitor.

    ≥98%
  • I5208

    INCB-28060

    c-MET inhibitor.

    ≥98%
  • T2402

    TG100-115

    p110δ and p110γ PI3K inhibitor.

    ≥98%
  • I4962

    Isoimperatorin

    Furocoumarin; COX-2 inhibitor.

    ≥98%
  • T2934

    Thiamphenicol Palmitate

    Chloramphenicol derivative; protein translation...

    ≥98%
  • H9712

    (E)-4-Hydroxytamoxifen

    SERM.

    ≥97%
  • S8344

    R,S-(±)-Sulpiride

    GHB agonist, D2/3 antagonist.

    ≥98%
  • E5200

    Enalaprilat Dihydrate

    Enalapril metabolite; ACE inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only