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Tranilast

Tranilast

Product ID T6902
Cas No. 53902-12-8
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $61.10 In stock
50 mg $132.60 In stock
100 mg $173.70 In stock
500 mg $510.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tranilast is an inhibitor of transient receptor potential vanilloid 2 (TRPV2) channels and PDGFRs; it is also a mast cell stabilizer. Tranilast exhibits anti-allergic, anti-fibrotic, immunomodulatory, anti-angiogenic, anti-metastatic, and anticancer chemotherapeutic activities. In animal models of fibrosis, tranilast inhibits mast cell filtration and decreases levels of α-SMA, collagen I, fibronectin, stem cell factor, and c-kit. In other animal models, this compound decreases allograft rejection and induces T cell anergy by increasing expression of p21 and p51, decreasing levels of IL-2, and stimulating cell cycle arrest. In cellular and animal models of breast cancer, tranilast induces G1/S phase cell cycle arrest, decreases levels of TGF-β1 and endoglin, increases levels of p53 and activation of caspase 3 and PARP, and inhibits cell migration, cell proliferation, and tumor growth. In vitro, tranilast inhibits VEGF- and FGF-induced cell proliferation, migration, and tube formation.

Product Info

Cas No.

53902-12-8

Purity

≥98%

Formula

C18H17NO5

Formula Wt.

327.34

Chemical Name

2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]- amino]benzoic acid

IUPAC Name

2-[[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]benzoic acid

Synonym

Rizaben, N-5'

Melting Point

211-213°C

Solubility

Soluble in DMSO (20 mg/mL), ethanol (2 mg/mL), DMF (35 mg/mL). Insoluble in water.

Appearance

Light yellow green crystal powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T6902 MSDS PDF

Info Sheet

T6902 Info Sheet PDF

References

Luo J, Li Y, Yang Y, et al. Role and mechanism of tranilast preventing the progression of tubulointerstilial fibrosis in diabetic kidney diseases. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 Dec;38(12):1233-42. PMID: 24384948.

Zaher SS, Coe D, Chai JG, et al. Suppression of the allogeneic response by the anti-allergy drug N-(3,4-dimethoxycinnamonyl) anthranilic acid results from T-cell cycle arrest. Immunology. 2013 Feb;138(2):157-64. PMID: 23121382.

Subramaniam V, Chakrabarti R, Prud'homme GJ, et al. Tranilast inhibits cell proliferation and migration and promotes apoptosis in murine breast cancer. Anticancer Drugs. 2010 Apr;21(4):351-61. PMID: 20145538.

Li Y, Liu FY, Peng YM, et al. Mast cell, a promising therapeutic target in tubulointerstitial fibrosis. Med Hypotheses. 2007;69(1):99-103. PMID: 17257770.

Watanabe S, Matsuda A, Suzuki Y, et al. Inhibitory mechanism of tranilast in human coronary artery smooth muscle cells proliferation, due to blockade of PDGF-BB-receptors. Br J Pharmacol. 2000 May;130(2):307-14. PMID: 10807667.

Koyama S, Takagi H, Otani A, et al. Tranilast inhibits protein kinase C-dependent signalling pathway linked to angiogenic activities and gene expression of retinal microcapillary endothelial cells. Br J Pharmacol. 1999 May;127(2):537-45. PMID: 10385256.

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